The administrative functions of the NU-PS-OC will operate under the aegis of the Robert H. Lurie Comprehensive Cancer and Chemistry of Life Processes Institute. The Administration will collectively provide oversight and facilitate interactions with: NCI program staff, the Center Advisory Committee (CAC), within the NU-PS-OC Center, the PS-OC Network, the PS-OC Steering Committee (PSC), and outside the PS-OC Network. In addition, the Administration will plan, implement and oversee day-to-day operations of the NU-PS-OC Center, the Pilot Project Program, the Trans-Network Project Program, the Outreach and Dissemination Unit, and the Education and Training Unit. The Principal Investigator is Jonathan Widom, PhD, a physical scientist who is Principal Investigator of the Keck Biophysics Facility at Northwestern University with appointments in Chemistry, Biochemistry, Molecular and Cell Biology. Dr. Widom's training, expertise, and extensive experience in physical science research, innovation, and education makes him ideally suited to lead the Physical Sciences-Oncology Center. The Senior Co-Investigator, Dr. Jonathan Licht, complements Dr. Widom by providing the perspective of a cancer researcher and clinician regarding theoretical and practical roadblocks to progress in cancer research. The close involvement of Dr. Steven T. Rosen, Director of the Robert H. Lurie Comprehensive Cancer Center with the NU-PS-OC Center as a member of the Center Advisory Committee will guarantee tight alignment of the Northwestern clinical oncology and tumor biology scientists with the physica scientists of the NU-PS-OC and will help expedite the dissemination of research breakthroughs throughout the cancer community. The participation of Thomas V. O'Halloran, Director of the Chemistry of Life Processes Institute, as an investigator on a PS-OC Project (Project 3), and PS-OC Center Advisory Committee, guarantees a mutually beneficial relationship between the NU-PS-OC and the Chemistry of Life Processes Institute. The Program Manager, Sheila M. Judge PhD, has a broad background in scientific research, teaching, and administration which will enable her to translate scientific and programmatic directives into operational goals and to work effectively with faculty and University administration to achieve those goals. An Assistant Project Manager will be responsible for the day-to-day operations of Center.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143869-02
Application #
7942783
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Program Officer
Nagahara, Larry
Project Start
2009-09-28
Project End
2014-07-31
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
2
Fiscal Year
2010
Total Cost
$2,653,359
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Serebryannyy, Leonid A; Yemelyanov, Alex; Gottardi, Cara J et al. (2017) Nuclear ?-catenin mediates the DNA damage response via ?-catenin and nuclear actin. J Cell Sci 130:1717-1729
Shah, M Y; Martinez-Garcia, E; Phillip, J M et al. (2016) MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene 35:5905-5915
Voong, Lilien N; Xi, Liqun; Sebeson, Amy C et al. (2016) Insights into Nucleosome Organization in Mouse Embryonic Stem Cells through Chemical Mapping. Cell 167:1555-1570.e15
Serebryannyy, Leonid A; Cruz, Christina M; de Lanerolle, Primal (2016) A Role for Nuclear Actin in HDAC 1 and 2 Regulation. Sci Rep 6:28460
Hill, Steven M; Heiser, Laura M; Cokelaer, Thomas et al. (2016) Inferring causal molecular networks: empirical assessment through a community-based effort. Nat Methods 13:310-8
Zhao, Baobing; Mei, Yang; Schipma, Matthew J et al. (2016) Nuclear Condensation during Mouse Erythropoiesis Requires Caspase-3-Mediated Nuclear Opening. Dev Cell 36:498-510
Serebryannyy, Leonid A; Parilla, Megan; Annibale, Paolo et al. (2016) Persistent nuclear actin filaments inhibit transcription by RNA polymerase II. J Cell Sci 129:3412-25
Chuang, Yishan; Hung, Michelle E; Cangelose, Brianne K et al. (2016) Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli. Innate Immun 22:647-657
Kreamer, Naomi N; Phillips, Rob; Newman, Dianne K et al. (2015) Predicting the impact of promoter variability on regulatory outputs. Sci Rep 5:18238
Mulligan, Peter J; Chen, Yi-Ju; Phillips, Rob et al. (2015) Interplay of Protein Binding Interactions, DNA Mechanics, and Entropy in DNA Looping Kinetics. Biophys J 109:618-29

Showing the most recent 10 out of 161 publications