Abstract

Public Health Relevance

This PS-OC brings together expert teams from the fields of physics, nano and microfabrication, engineering and cancer biology to develop novel trans-disciplinary approaches to better understand the complexity of cancer metastasis, the aspect of cancer that directly leads to patient morbidity and mortality. Approaches developed by physical scientists will be focused on the study of cancer. Our studies aim to identify novel mechanisms used by cancer cells, but not normal cells, for growth and metastasis to distant body sites. These new mechanism provide novel drug targets, that aim towards arresting cancer metastasis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA143876-01
Application #
7796234
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Project Start
2010-01-01
Project End
2014-07-31
Budget Start
2010-01-01
Budget End
2010-07-31
Support Year
1
Fiscal Year
2009
Total Cost
$364,502
Indirect Cost

  Institution

Name
Cornell University
Department
Type
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850

  Publications

Ariza-Nieto, Magnolia; Alley, Joshua B; Samy, Sanjay et al. (2018) Circulating miR-148a associates with sensitivity to adiponectin levels in human metabolic surgery for weight loss. Endocr Connect :
Song, Young Hye; Warncke, Christine; Choi, Sung Jin et al. (2017) Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells. Matrix Biol 60-61:190-205
Carey, Shawn P; Martin, Karen E; Reinhart-King, Cynthia A (2017) Three-dimensional collagen matrix induces a mechanosensitive invasive epithelial phenotype. Sci Rep 7:42088
Huang, Yu Ling; Segall, Jeffrey E; Wu, Mingming (2017) Microfluidic modeling of the biophysical microenvironment in tumor cell invasion. Lab Chip 17:3221-3233
Wang, Suming; Blois, Anna; El Rayes, Tina et al. (2016) Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment. Sci Transl Med 8:329ra34
Mittal, Vivek (2016) Epithelial Mesenchymal Transition in Aggressive Lung Cancers. Adv Exp Med Biol 890:37-56
McDowell, Gary; Rajadurai, Suvithan; Levin, Michael (2016) From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning. Philos Trans R Soc Lond B Biol Sci 371:
Sharkey, Charles C; Li, Jiahe; Roy, Sweta et al. (2016) Two-stage nanoparticle delivery of piperlongumine and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) anti-cancer therapy. Technology (Singap World Sci) 4:60-69
Cao, Xuan; Moeendarbary, Emad; Isermann, Philipp et al. (2016) A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration. Biophys J 111:1541-1552
Song, Young Hye; Shon, Seung Hee; Shan, Mengrou et al. (2016) Adipose-derived stem cells increase angiogenesis through matrix metalloproteinase-dependent collagen remodeling. Integr Biol (Camb) 8:205-15

Showing the most recent 10 out of 197 publications