We propose that Cancer is a dynamic complex multiscale system that can only truly be understood via the integration of theory and experiments. The goal of the proposal is to use such an integrated approach to better understand, predict and treat cancer
| Gatenby, Robert; Brown, Joel (2018) The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med 8: |
| Gravenmier, Curtis A; Siddique, Miriam; Gatenby, Robert A (2018) Adaptation to Stochastic Temporal Variations in Intratumoral Blood Flow: The Warburg Effect as a Bet Hedging Strategy. Bull Math Biol 80:954-970 |
| Ibrahim-Hashim, Arig; Robertson-Tessi, Mark; Enriquez-Navas, Pedro M et al. (2017) Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res 77:2242-2254 |
| Brown, Joel S; Cunningham, Jessica J; Gatenby, Robert A (2017) Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer. IEEE Trans Biomed Eng 64:512-518 |
| Perfahl, Holger; Hughes, Barry D; Alarcón, Tomás et al. (2017) 3D hybrid modelling of vascular network formation. J Theor Biol 414:254-268 |
| de Groot, Amber E; Roy, Sounak; Brown, Joel S et al. (2017) Revisiting Seed and Soil: Examining the Primary Tumor and Cancer Cell Foraging in Metastasis. Mol Cancer Res 15:361-370 |
| Gatenby, Robert A; Frieden, B Roy (2017) Cellular information dynamics through transmembrane flow of ions. Sci Rep 7:15075 |
| McFarland, Christopher D; Yaglom, Julia A; Wojtkowiak, Jonathan W et al. (2017) The Damaging Effect of Passenger Mutations on Cancer Progression. Cancer Res 77:4763-4772 |
| Zhang, Jingsong; Cunningham, Jessica J; Brown, Joel S et al. (2017) Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer. Nat Commun 8:1816 |
| Scott, Jacob G; Fletcher, Alexander G; Anderson, Alexander R A et al. (2016) Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model. PLoS Comput Biol 12:e1004712 |
Showing the most recent 10 out of 121 publications
