The PS-OC is itself a highly collaborative structure as virtually every key member of the PS-OC is involved in multiple projects and infrastructure components. Additional collaborations within the PS-OC will be encouraged through weekly conferences in the IMO at Moffitt, monthly videoconferences of the PS-OC research groups, and face-to-face interactions that will occur through the summer school and yearly international conference both sponsored by the PS-OC. We have placed a facilitator in the mathematics/computation core to promote the often difficult initial steps in these multidisciplinary interactions. Further collaborations will be encouraged through the co-mentoring of PhD students described in section N3. We will also encourage collaborations with members of other PS-OCs by providing funding for a visiting scholar program that will each year fund 10 scholars to spend an average of 3 months (range from 1 to 6 months) in one component of the IMO PS-OC. Similarly, funds will be set aside for members of the IMO PS-OC to visit other sites to either obtain advanced training or use research/educational facilities that might be unique to that site.
| Gatenby, Robert; Brown, Joel (2018) The Evolution and Ecology of Resistance in Cancer Therapy. Cold Spring Harb Perspect Med 8: |
| Gravenmier, Curtis A; Siddique, Miriam; Gatenby, Robert A (2018) Adaptation to Stochastic Temporal Variations in Intratumoral Blood Flow: The Warburg Effect as a Bet Hedging Strategy. Bull Math Biol 80:954-970 |
| Ibrahim-Hashim, Arig; Robertson-Tessi, Mark; Enriquez-Navas, Pedro M et al. (2017) Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res 77:2242-2254 |
| Brown, Joel S; Cunningham, Jessica J; Gatenby, Robert A (2017) Aggregation Effects and Population-Based Dynamics as a Source of Therapy Resistance in Cancer. IEEE Trans Biomed Eng 64:512-518 |
| Perfahl, Holger; Hughes, Barry D; Alarcón, Tomás et al. (2017) 3D hybrid modelling of vascular network formation. J Theor Biol 414:254-268 |
| de Groot, Amber E; Roy, Sounak; Brown, Joel S et al. (2017) Revisiting Seed and Soil: Examining the Primary Tumor and Cancer Cell Foraging in Metastasis. Mol Cancer Res 15:361-370 |
| Gatenby, Robert A; Frieden, B Roy (2017) Cellular information dynamics through transmembrane flow of ions. Sci Rep 7:15075 |
| McFarland, Christopher D; Yaglom, Julia A; Wojtkowiak, Jonathan W et al. (2017) The Damaging Effect of Passenger Mutations on Cancer Progression. Cancer Res 77:4763-4772 |
| Zhang, Jingsong; Cunningham, Jessica J; Brown, Joel S et al. (2017) Integrating evolutionary dynamics into treatment of metastatic castrate-resistant prostate cancer. Nat Commun 8:1816 |
| Scott, Jacob G; Fletcher, Alexander G; Anderson, Alexander R A et al. (2016) Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model. PLoS Comput Biol 12:e1004712 |
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