Abstract

Follicular Lymphoma: An Indolent Malignancy That is Incurable. FL arises from a single mature B lymphocyte that has rearranged and expressed a unique set of immunoglobulin heavy and light chain variable region genes, but that also has rearranged and deregulated the expression of the BCL2 anti-apoptotic gene. We suspect that the immunoglobulin B cell receptor transmits growth and survival signals to the developing tumor clone, perhaps from an unidentified antigen stimulus. Through a series of further genetic changes a more malignant subclone can emerge that often results in the death of the patient. During a long indolent phase the tumor can respond to a variety of chemotherapy drugs, radiotherapy treatments and immunological therapies, such as monoclonal antibodies, but the disease is uniformly incurable. There is no suitable animal model for human FL and therefore our understanding of the biology of this malignant disease is necessarily restricted to an analysis of tumor specimens obtained from patients at various stages of the malignant progression.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA149145-05
Application #
8628778
Study Section
Special Emphasis Panel (ZCA1-SRLB-C)
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
5
Fiscal Year
2014
Total Cost
$157,586
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Anchang, Benedict; Davis, Kara L; Fienberg, Harris G et al. (2018) DRUG-NEM: Optimizing drug combinations using single-cell perturbation response to account for intratumoral heterogeneity. Proc Natl Acad Sci U S A 115:E4294-E4303
Good, Zinaida; Sarno, Jolanda; Jager, Astraea et al. (2018) Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse. Nat Med 24:474-483
Banovich, Nicholas E; Li, Yang I; Raj, Anil et al. (2018) Impact of regulatory variation across human iPSCs and differentiated cells. Genome Res 28:122-131
Sinha, Subarna; Thomas, Daniel; Chan, Steven et al. (2017) Systematic discovery of mutation-specific synthetic lethals by mining pan-cancer human primary tumor data. Nat Commun 8:15580
Knowles, David A; Davis, Joe R; Edgington, Hilary et al. (2017) Allele-specific expression reveals interactions between genetic variation and environment. Nat Methods 14:699-702
O'Gorman, W E; Kong, D S; Balboni, I M et al. (2017) Mass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patients. J Autoimmun :
Li, Yang I; van de Geijn, Bryce; Raj, Anil et al. (2016) RNA splicing is a primary link between genetic variation and disease. Science 352:600-4
Anchang, Benedict; Hart, Tom D P; Bendall, Sean C et al. (2016) Visualization and cellular hierarchy inference of single-cell data using SPADE. Nat Protoc 11:1264-79
Angst, Martin S; Fragiadakis, Gabriela K; Gaudillière, Brice et al. (2016) In Reply. Anesthesiology 124:1414-5
Aghaeepour, Nima; Chattopadhyay, Pratip; Chikina, Maria et al. (2016) A benchmark for evaluation of algorithms for identification of cellular correlates of clinical outcomes. Cytometry A 89:16-21

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