Laboratories: Bioinformatics. Svstems Biology, Clinical Informatics. Medical Image Analvsis, Optical Imaging. Animal Imaging and Molecular Imaging Laboratories of The Centerfor Biotechnology and Informatics (CBI). TMHRI and Research Department of Radiologv at Fondren/Brown Translation Research Laboratories The Fondren/Brown Translation Research Laboratories in the Methodist Research Institute are state-of-the-art flexible, open design, modular laboratories. The Fondren/Brown laboratories encompass approximately 80,000 square feet of """"""""wet"""""""" and """"""""dry"""""""" laboratory research space. Specifically, the 5th Floor (approximately 30,000 square feet) ofthe Fondren/Brown Building was renovated and will provide the support laboratory space for this grant. Over 4,000 square feet of this laboratory will be dedicated to Dr. Wong's bioinformatics and imaging research program and will be used for this grant proposal. The microscopy and molecular imaging lab. medical systems biology wet lab. research databases, in vitro molecular biology, chemistry, and proteomics experiments will be performed in this space. The laboratory space is bordered by support rooms including a linear equipment room, environmental rooms, tissue culture rooms, and specialized equipment/procedure rooms. Directly adjacent to the laboratory space is the Fondren vivarium that is used as a core facility. The proximity of this vivarium to Dr. Wong's laboratory offers ease of transport for animal related experiments as well as access to procedure rooms located within the vivarium itself. In addition, about 2,000 sq feet at the 7""""""""^ Floor ofthe Fondren/Brown Building houses the microscopy core lab of the high content screening microscopy system, confocal microscopy, and LCM (laser capture microscopy) as well as physics and medical instrumentation laboratory, both directed by Dr. Wong also. Another 4,000 sq feet at the 3^''floor of West Pavillion Building of The Methodist Hospital hosts the biomedical instrumentation and biomedical computing labs and a large dedicated conference room of Dr. Wong's Center of Biotechnology and Informatics Program.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Methodist Hospital Research Institute
United States
Zip Code
Leung, Cecilia S; Yeung, Tsz-Lun; Yip, Kay-Pong et al. (2018) Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance. J Clin Invest 128:589-606
Wang, Hai; Tian, Lin; Liu, Jun et al. (2018) The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability. Cancer Cell 34:823-839.e7
Yu, Yaping; Kong, Ren; Cao, Huojun et al. (2018) Two birds, one stone: hesperetin alleviates chemotherapy-induced diarrhea and potentiates tumor inhibition. Oncotarget 9:27958-27973
Liu, Yi; Choi, Dong Soon; Sheng, Jianting et al. (2018) HN1L Promotes Triple-Negative Breast Cancer Stem Cells through LEPR-STAT3 Pathway. Stem Cell Reports 10:212-227
Rosato, Roberto R; Dávila-González, Daniel; Choi, Dong Soon et al. (2018) Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models. Breast Cancer Res 20:108
Ren, Ding; Zhu, Xiaoping; Kong, Ren et al. (2018) Targeting Brain-Adaptive Cancer Stem Cells Prohibits Brain Metastatic Colonization of Triple-Negative Breast Cancer. Cancer Res 78:2052-2064
Guven, Adem; Villares, Gabriel J; Hilsenbeck, Susan G et al. (2017) Carbon nanotube capsules enhance the in vivo efficacy of cisplatin. Acta Biomater 58:466-478
Chen, Suyun; Ibrahim, Nuhad K; Yan, Yuanqing et al. (2017) Complete Metabolic Response on Interim18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography to Predict Long-Term Survival in Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy. Oncologist 22:526-534
Neelakantan, Deepika; Zhou, Hengbo; Oliphant, Michael U J et al. (2017) EMT cells increase breast cancer metastasis via paracrine GLI activation in neighbouring tumour cells. Nat Commun 8:15773
Dong, J; Zhao, W; Shi, A et al. (2016) The PR status of the originating cell of ER/PR-negative mouse mammary tumors. Oncogene 35:4149-54

Showing the most recent 10 out of 106 publications