The Center of Cancer Systems Biology (CCSB) St. Elizabeth's Medical Center, Tufts Univ School of Med (TUSM), brings together diverse researchers from biological, mathematical, physical and clinical backgrounds to better understand the molecular and fissue-level events underlying cancer evolufion and development. In the three years since its founding the CCSB has matured into a well-established, deeply interactive and mulfidisciplinary cancer group which it is becoming an internafionally competifive research and training facility and research data repository in cancer systems biology Tufts CCSB has already been the recipient of two federally funded multidisciplinary Program Project Grants on carcinogenesis. Each combines mathemafical and computafional modeling with state-of the art experimental cancer biology. The first is a NASA Specialized Center of Research (NSCOR) funded to study risk of solid tumor carcinogenesis from space radiafion exposure ($10 Million;PI Dr. HIatky). The second is a DOE-funded center to study carcinogenesis risk following low-dose radiation exposure from background radiation ($7.5 million to Dr. HIatky and 1 million to Dr. Hahnfeldt for mathematical analysis of this issue). Clearly, both the PI and the Center are well-versed in running large program grants on carcinogenesis. Funding of this ICBP applicafion would provide an opportunity to connect this established CCSB with the nafional networks of ICBP-funded Centers around the country also embarking on predicfive cancer modeling and thereby contribute to the NCI directed goals of this Program. Nicolaos Madias, MD, Director of Medicine, SEMC, TUSM made deliberate strategic decisions in establishing the CCSB, recruifing Dr. HIatky as director, and the dedicafion of laboratory research space and compufing resources, as well as the subsequent expansion of her group, represents a major insfitufional investment and confinuing commitment to innovafive, cuffing edge cancer research. SEMC has backed up this research commitment with a massive expansion plan being implemented for its clinical services at the Oncology Center, involving an addifional 8,000 sq ft for Rad One and an addifional 8,000 sq ft for Medical Oncology (see support letter Dr. Madias). The breadth and depth of SEMC's commitment to this long-term strategic set of goals is clear. The confinuing strength of the intellectual, academic, and training environment is reinforced by Research faculty as well as clinical training appointments through TUSM.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-C)
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Genesys Research Institute, Inc.
United States
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Wilkie, Kathleen P; Hahnfeldt, Philip (2017) Modeling the Dichotomy of the Immune Response to Cancer: Cytotoxic Effects and Tumor-Promoting Inflammation. Bull Math Biol 79:1426-1448
Benzekry, Sebastien; Lamont, Clare; Barbolosi, Dominique et al. (2017) Mathematical Modeling of Tumor-Tumor Distant Interactions Supports a Systemic Control of Tumor Growth. Cancer Res 77:5183-5193
Gao, Xuefeng; Sishc, Brock J; Nelson, Christopher B et al. (2016) Radiation-Induced Reprogramming of Pre-Senescent Mammary Epithelial Cells Enriches Putative CD44(+)/CD24(-/low) Stem Cell Phenotype. Front Oncol 6:138
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Pellicciotta, Ilenia; Marciscano, Ariel E; Hardee, Matthew E et al. (2015) Development of a novel multiplexed assay for quantification of transforming growth factor-? (TGF-?). Growth Factors 33:79-91
Benzekry, Sebastian; Tuszynski, Jack A; Rietman, Edward A et al. (2015) Design principles for cancer therapy guided by changes in complexity of protein-protein interaction networks. Biol Direct 10:32
Beheshti, Afshin; Benzekry, S├ębastien; McDonald, J Tyson et al. (2015) Host age is a systemic regulator of gene expression impacting cancer progression. Cancer Res 75:1134-43
Kareva, Irina; Waxman, David J; Lakka Klement, Giannoula (2015) Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance. Cancer Lett 358:100-106
Poleszczuk, Jan; Hahnfeldt, Philip; Enderling, Heiko (2015) Evolution and phenotypic selection of cancer stem cells. PLoS Comput Biol 11:e1004025
Benzekry, Sebastien; Beheshti, Afshin; Hahnfeldt, Philip et al. (2015) Capturing the Driving Role of Tumor-Host Crosstalk in a Dynamical Model of Tumor Growth. Bio Protoc 5:

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