As an integral part of the CCNE, we propose to create a pre-doctoral and post-doctoral training program in cancer nanomedicine that will: (1) bridge the gap in language and skills between the physical sciences/engineering and cancer biology/oncology communities, (2) contribute to the creation of new knowledge and new technologies, and (3) train a new generation of multidisciplinary scientists and engineers in cancer nanomedicine.
SPECIFIC AIMS Aim 1 (Education/Training). To recruit pre-doctoral students and post-doctoral fellows with backgrounds in the biological sciences, physical sdences, or engineering. Special efforts will be conducted to recruit, retain, and mentor trainees from under-represented groups.
Aim 2 (Education/Training). To train a new generation of mulddisciplinary scientists, engineers, and clinicians in cancer nanomedicine.
Aim 3 (Education/Training). To provide students and fellows the opportunity to conduct research in cancer nanomedicine. Each trainee will be co-mentored by at least one faculty in the physical sciences/engineering and at least one faculty in cancer biology/oncology.
Aim 4 (Education/Training and Outreach). To provide CCNE researchers the opportunity to visit other CCNEs by establishing an exchange program.
Aim 5 (Outreach). Establish a comprehensive set of outreach activities to disseminate the new knowledge and new technologies created in the proposed CCNE to the relevant scientific communities and constituencies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA151838-01
Application #
7984068
Study Section
Special Emphasis Panel (ZCA1-GRB-S (M1))
Project Start
2010-08-25
Project End
2015-07-31
Budget Start
2010-09-01
Budget End
2011-07-31
Support Year
1
Fiscal Year
2010
Total Cost
$85,738
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Russell, Luisa M; Hultz, Margot; Searson, Peter C (2018) Leakage kinetics of the liposomal chemotherapeutic agent Doxil: The role of dissolution, protonation, and passive transport, and implications for mechanism of action. J Control Release 269:171-176
Woodard, Lauren E; Dennis, Cindi L; Borchers, Julie A et al. (2018) Nanoparticle architecture preserves magnetic properties during coating to enable robust multi-modal functionality. Sci Rep 8:12706
Pisanic 2nd, Thomas R; Athamanolap, Pornpat; Wang, Tza-Huei (2017) Defining, distinguishing and detecting the contribution of heterogeneous methylation to cancer heterogeneity. Semin Cell Dev Biol 64:5-17
Liu, Guanshu; Ray Banerjee, Sangeeta; Yang, Xing et al. (2017) A dextran-based probe for the targeted magnetic resonance imaging of tumours expressing prostate-specific membrane antigen. Nat Biomed Eng 1:977-982
Huang, Xinglu; Chisholm, Jane; Zhuang, Jie et al. (2017) Protein nanocages that penetrate airway mucus and tumor tissue. Proc Natl Acad Sci U S A 114:E6595-E6602
Dawidczyk, Charlene M; Russell, Luisa M; Hultz, Margot et al. (2017) Tumor accumulation of liposomal doxorubicin in three murine models: Optimizing delivery efficiency. Nanomedicine 13:1637-1644
Wu, Juan; Qu, Wei; Williford, John-Michael et al. (2017) Improved siRNA delivery efficiency via solvent-induced condensation of micellar nanoparticles. Nanotechnology 28:204002
Schneider, Craig S; Xu, Qingguo; Boylan, Nicholas J et al. (2017) Nanoparticles that do not adhere to mucus provide uniform and long-lasting drug delivery to airways following inhalation. Sci Adv 3:e1601556
Banerjee, Sangeeta R; Foss, Catherine A; Horhota, Allen et al. (2017) 111In- and IRDye800CW-Labeled PLA-PEG Nanoparticle for Imaging Prostate-Specific Membrane Antigen-Expressing Tissues. Biomacromolecules 18:201-209
Shin, Soo Hyun; Kadayakkara, Deepak K; Bulte, Jeff W M (2017) In Vivo (19)F MR Imaging Cell Tracking of Inflammatory Macrophages and Site-specific Development of Colitis-associated Dysplasia. Radiology 282:194-201

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