Abstract

PHYSICO-CHEIVIICAL NANOCHARACTERIZATION CORE . The role of this core will be to provide the necessary physico-chemical characterization of nanopreparations such as polymeric nanoparticles, lipid nanoparticles, dendrimers, and selfassembling nanosystems prepared in all the CCNE projects. An array of sophisticated microscopic, spectroscopic and analytical tools are available to study the size, size distribution, stability, surface charge, and drug loading/release from these nanopreparations. This core brings expertise in the basic science and engineering aspects of nanotechnology that is essential to understand the fundamental properties of these nanopreparations. Feedback from this core will help the scientists engaged in these projects to optimize these nanopreparations for successful use in cancer therapy. This core will also work in parallel with Nano Characterization Laboratory (NCL) to facilitate the overall mission of this CCNE to translate basic research to industrial production of nanomedicines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA151881-02
Application #
8327149
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
2
Fiscal Year
2011
Total Cost
$89,914
Indirect Cost

  Institution

Name
Northeastern University
Department
Type
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Jhaveri, Aditi; Deshpande, Pranali; Pattni, Bhushan et al. (2018) Transferrin-targeted, resveratrol-loaded liposomes for the treatment of glioblastoma. J Control Release 277:89-101
Wang, Tao; Narayanaswamy, Radhika; Ren, Huilan et al. (2018) Phage-derived protein-mediated targeted chemotherapy of pancreatic cancer. J Drug Target 26:505-515
Kumar, Gaurav; Goldberg, S Nahum; Gourevitch, Svetlana et al. (2018) Targeting STAT3 to Suppress Systemic Pro-Oncogenic Effects from Hepatic Radiofrequency Ablation. Radiology 286:524-536
Upponi, Jaydev R; Jerajani, Kaushal; Nagesha, Dattatri K et al. (2018) Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents. Biomaterials 170:26-36
Petrenko, Valery A; Gillespie, James W (2017) Paradigm shift in bacteriophage-mediated delivery of anticancer drugs: from targeted 'magic bullets' to self-navigated 'magic missiles'. Expert Opin Drug Deliv 14:373-384
van de Ven, Anne L; Tangutoori, Shifalika; Baldwin, Paige et al. (2017) Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation. Mol Cancer Ther 16:1279-1289
Pattni, Bhushan S; Jhaveri, Aditi; Dutta, Ivy et al. (2017) Targeting energy metabolism of cancer cells: Combined administration of NCL-240 and 2-DG. Int J Pharm 532:149-156
Pattni, Bhushan S; Nagelli, Srikar G; Aryasomayajula, Bhawani et al. (2016) Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model. Pharm Res 33:2540-51
Sriraman, Shravan Kumar; Salzano, Giusseppina; Sarisozen, Can et al. (2016) Anti-cancer activity of doxorubicin-loaded liposomes co-modified with transferrin and folic acid. Eur J Pharm Biopharm 105:40-9
Perche, Federico; Biswas, Swati; Patel, Niravkumar R et al. (2016) Hypoxia-Responsive Copolymer for siRNA Delivery. Methods Mol Biol 1372:139-62

Showing the most recent 10 out of 86 publications