CCN II PILOT RESEARCH PROJECT PROJECT TITLE PAGE PROJECT TITLE: Understanding and Improving NCI Trial Enrollment among African Americans in North Carolina PROJECT LEADER: William Carpenter, PhD, MHA PROJECT SUMMARY: The goals of the proposed Pilot study are to systematically analyze and understand enrollment patterns in NCI clinical trials in North Carolina, and assess strengths and weaknesses of specific interventions to increase minority enrollment in collaborafion with community partners. The Pilot seeks to Inform efforts to increase knowledge, access, and use of beneficial biomedical and behavioral procedures in cancer disparifies. It serves primarily as a research educafion experience for the Pilot Project Director (William Carpenter, PhD), an eariy-stage invesfigator with a career focus in racial disparifies in cancer care and outcomes. The Pilot will apply his experience in quantitative analysis to a cancer-focused problem in racial disparities, and provides a mentored training experience to build skills in CBPR, qualitative research methods, and intervention development The Pilot addresses the CNP goals of using CBPR to assess knowledge, attitudes, and behaviors of racial/ethnic minorifies and underserved populafions regarding participation in NCI sponsored clinical trials. It does so by refining and applying a novel population-based method of systematically measuring county-level overall and minority clinical trial enrollment rates in North Carolina since 1995. It will use participatory methods with our CCN Community Outreach Program (COP) partners in the Greensboro Area Health Educafion Center (GAHEC) and Area-L AHEC regions (ALAHEC) to collaboratively interpret the observed enrollment patterns, and will convene focus groups with minority cancer survivors to assess specific educafional interventions being developed in the Cancer Clinical Trials learning cluster. The focus groups findings will inform refinement of the interventions, contribufing to their improved effectiveness in educating the community and enrolling minorities in clinical trials. The pilot will contribute to the CCN-ll program's community infrastructure and sustainability, and provide data for a future ROI applicafion. The Director of the NCI Community Clinical Oncology Program (CCOP) and Minority-based CCOP (MBCCOP) has indicated a strong interest in disseminating these interventions through the CCOP network, and supporting the R01-funded examination of their effectiveness.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Vines, Anissa I; Hunter, Jaimie C; Carlisle, Veronica A et al. (2017) Prostate Cancer Ambassadors: Process and Outcomes of a Prostate Cancer Informed Decision-Making Training Program. Am J Mens Health 11:54-62
Vines, Anissa I; Melvin, Cathy L; Hunter, Jaimie C et al. (2017) Project ACCRUE: Exploring Options to Increase Awareness of AIDS Malignancy Consortium Clinical Trials in North Carolina. N C Med J 78:84-91
Robinson, Whitney R; Cheng, Mariah M; Howard, Annie Green et al. (2017) For U.S. Black women, shift of hysterectomy to outpatient settings may have lagged behind White women: a claims-based analysis, 2011-2013. BMC Health Serv Res 17:526
Carney, Timothy Jay; Kong, Amanda Y (2017) Leveraging health informatics to foster a smart systems response to health disparities and health equity challenges. J Biomed Inform 68:184-189
Vines, Anissa I; Hunter, Jaimie C; Carlisle, Veronica A et al. (2017) Prostate Cancer Ambassadors: Enhancing a Theory-Informed Training Program for Informed Decision-Making. J Cancer Educ 32:454-459
Cobran, Ewan K; Merino, Yesenia; Roach, Beth et al. (2017) The Independent Specialty Medical Advocate Model of Patient Navigation and Intermediate Health Outcomes in Newly Diagnosed Cancer Patients. J Oncol Navig Surviv 8:454-462
Vines, Anissa I; Carpenter, William R; Chen, Ronald C et al. (2017) Responding to a Community's Concern: A Comparison of Breast Cancer Characteristics and Initial Treatment in Three Selected North Carolina Counties. N C Med J 78:357-365
Cobran, Ewan K; Hall, Jori N; Aiken, William D (2017) African-American and Caribbean-Born Men's Perceptions of Prostate Cancer Fear and Facilitators for Screening Behavior: a Pilot Study. J Cancer Educ :
Zullig, Leah L; Carpenter, William R; Williams, Christina D (2017) Next steps to improve disparities in lung cancer treatment clinical trial enrollment. Ann Transl Med 5:118
Carney, Timothy Jay; Shea, Christopher Michael (2017) Informatics Metrics and Measures for a Smart Public Health Systems Approach: Information Science Perspective. Comput Math Methods Med 2017:1452415

Showing the most recent 10 out of 33 publications