Pilot Project: Development of a family-based clinical trials intervention for rural, Appalachian cancer patients Project Leader: Janice Raup-Krieger, PhD Key Personnel and Calendar month effort: Janice Raup-Krieger, PhD, 3.00 calendar months (1.8 academic, 1.2 summer) Electra Paskett, PhD (Mentor) (1.20 calendar months on Research Program and 0.6 on Administrative Core) Nancy Schoenberg, PhD (Mentor) (1.20 calendar months on Administrative Core) Project Summary: Guided by multiple goals theory, the purpose of the proposed study is to develop and pilot test a culturally grounded, family-based intervention to assist cancer patients living in Appalachia and their families in making a decision about participation in a clinical treatment trial. The development of the intervention will be informed by two sources: (1) in-depth interviews conducted with cancer patients who had previously been offered a clinical treatment trial and their family members and (2) input from members of the Appalachia Community Cancer Network (ACCN) community cancer coalitions. Upon completion of data collection and analysis, the intervention will be pilot tested with ten different newly diagnosed cancer patients and their families. In the pilot test, a patient navigator will facilitate a family discussion about participation in a Phase III clinical trial using the intervention video and other educational materials. The results of the pilot test will be used as the basis of an R21 grant to test the efficacy of the intervention. The training component of the award will focus on broadening Dr. Krieger's expertise in health communication to include community-based participatory research (CBPR). Dr. Krieger will complete an intensive summer course on CBPR as well as attend monthly workshops facilitated by the ACCN. In addition, Dr. Krieger will meet on a weekly or bi-weekly basis with her mentors, Dr. Electra Paskett (Ohio State University-Epidemiology) and Dr. Nancy Schoenberg (University of Kentucky-Medical Anthropology), both of whom have extensive experience with CBPR methods in Appalachia.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-PCRB-G (M1))
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University of Kentucky
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Paskett, Electra D; Baltic, Ryan D; Young, Gregory S et al. (2018) A Group Randomized Trial to Reduce Obesity among Appalachian Church Members: The Walk by Faith Study. Cancer Epidemiol Biomarkers Prev 27:1289-1297
Palmer-Wackerly, Angela L; Dailey, Phokeng M; Krok-Schoen, Jessica L et al. (2018) Patient Perceptions of Illness Identity in Cancer Clinical Trial Decision-Making. Health Commun 33:1045-1054
Krieger, Janice L; Palmer-Wackerly, Angela; Dailey, Phokeng M et al. (2015) Comprehension of Randomization and Uncertainty in Cancer Clinical Trials Decision Making Among Rural, Appalachian Patients. J Cancer Educ 30:743-8
Baltic, Ryan D; Weier, Rory C; Katz, Mira L et al. (2015) Study design, intervention, and baseline characteristics of a group randomized trial involving a faith-based healthy eating and physical activity intervention (Walk by Faith) to reduce weight and cancer risk among overweight and obese Appalachian adults. Contemp Clin Trials 44:1-10
Garcia-Dominic, Oralia; Lengerich, Eugene J; Camacho, Fabian et al. (2014) Prevalence of diabetes and associated obesity in Pennsylvania adults, 1995-2010. Prev Chronic Dis 11:E111
Spleen, Angela M; Lengerich, Eugene J; Camacho, Fabian T et al. (2014) Health care avoidance among rural populations: results from a nationally representative survey. J Rural Health 30:79-88
Palmer-Wackerly, Angela L; Krok, Jessica L; Dailey, Phokeng M et al. (2014) Community engagement as a process and an outcome of developing culturally grounded health communication interventions: an example from the DECIDE project. Am J Community Psychol 53:261-74
Gallant, Nancy R; Corbin, Marilyn; Bencivenga, Marcyann M et al. (2013) Adaptation of an evidence-based intervention for Appalachian women: new STEPS (Strength Through Education, Physical fitness and Support) for breast health. J Cancer Educ 28:275-81
Aumiller, Betsy B; Parrott, Roxanne; Lengerich, Eugene J et al. (2013) Responses to a theoretically adapted clinical trial education session: faith-based sites versus rural work site dissemination. J Cancer Educ 28:698-708