Abstract

This proposed Research Center aims to establish a multi-disciplinary, multi-institutional program to develop, optimize, and validate a targeted imaging strategy for the early detection and prevention of cancer in patients with Barrett's esophagus. This research team is formed from world leading investigators from the University of Michigan, University of Washington, and the Mayo Clinic, and has major strengths in clinical and translational research in Barrett's esophagus, genomics, molecular imaging, engineering, bioinfomatics, modeling and pathology. The key members of this team have demonstrated previous collaborations using funding provided by developmental projects in the Network for Translational Research (NTR), a consortium of academic institutions and industrial partners who are working together to develop novel methods for the early detection of colorectal cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163059-02
Application #
8555333
Study Section
Special Emphasis Panel (ZCA1-SRLB-1 (O1))
Project Start
2011-09-21
Project End
2016-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
2
Fiscal Year
2012
Total Cost
$193,963
Indirect Cost
$61,943

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Chen, Jing; Gao, Zhenghong; Li, Gaoming et al. (2018) Dual-modal in vivo fluorescence and photoacoustic imaging using a heterodimeric peptide. Chem Commun (Camb) 54:13196-13199
Joshi, Bishnu P; Wang, Thomas D (2018) Targeted Optical Imaging Agents in Cancer: Focus on Clinical Applications. Contrast Media Mol Imaging 2018:2015237
Rubenstein, Joel H; Waljee, Akbar K; Dwamena, Ben et al. (2018) Yield of Higher-Grade Neoplasia in Barrett's Esophagus With Low-Grade Dysplasia Is Double in the First Year Following Diagnosis. Clin Gastroenterol Hepatol 16:1529-1530
Tavakkoli, Anna; Appelman, Henry D; Beer, David G et al. (2018) Use of Appropriate Surveillance for Patients With Nondysplastic Barrett's Esophagus. Clin Gastroenterol Hepatol 16:862-869.e3
Stachler, Matthew D; Camarda, Nicholas D; Deitrick, Christopher et al. (2018) Detection of Mutations in Barrett's Esophagus Before Progression to High-Grade Dysplasia or Adenocarcinoma. Gastroenterology 155:156-167
Jiang, Yang; Gong, Yuanzheng; Rubenstein, Joel H et al. (2017) Toward real-time quantification of fluorescence molecular probes using target/background ratio for guiding biopsy and endoscopic therapy of esophageal neoplasia. J Med Imaging (Bellingham) 4:024502
Savastano, Luis E; Seibel, Eric J (2017) Scanning Fiber Angioscopy: A Multimodal Intravascular Imaging Platform for Carotid Atherosclerosis. Neurosurgery 64:188-198
Zhou, Juan; He, Lei; Pang, Zhijun et al. (2017) Identification and validation of FGFR2 peptide for detection of early Barrett's neoplasia. Oncotarget 8:87095-87106
Savastano, Luis E; Zhou, Quan; Smith, Arlene et al. (2017) Multimodal laser-based angioscopy for structural, chemical and biological imaging of atherosclerosis. Nat Biomed Eng 1:
Ferrer-Torres, Daysha; Nancarrow, Derek J; Kuick, Rork et al. (2016) Genomic similarity between gastroesophageal junction and esophageal Barrett's adenocarcinomas. Oncotarget 7:54867-54882

Showing the most recent 10 out of 45 publications