Abstract

SPECIFIC AIMS The long term goal of this collaborative research project is to determine whether tumor-specific exosomal proteins may aid in the diagnosis and/or management of patients with breast and colorectal cancer. It is important to emphasize that the study of serum exosomes in health and disease is a nascent field of inquiry and there are many unanswered questions. Although exosomes have been found in the serum of normal individuals and cancer patients, it is unknown whether there are quantitative and/or qualitative differences in the levels and/or the composition of serum exosomes in these two populations. Before embarking on this analysis, it will be important to determine whether there are differences in serum exosomes among normal individuals based on age, sex and race. This is important baseline information. We will then determine if there are differences in serum exosomes between normal individuals and cancer patients. We will compare patients with early stage and advanced cancers, and whether the composition of serum exosomes changes in response to treatment. These preliminary studies will help determine the ultimate role of serum exosomes in the diagnosis and management of patients with breast and colorectal cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA163069-01
Application #
8261513
Study Section
Special Emphasis Panel (ZCA1-SRLB-Y (O1))
Project Start
2011-09-26
Project End
2016-08-31
Budget Start
2011-09-26
Budget End
2012-08-31
Support Year
1
Fiscal Year
2011
Total Cost
$76,842
Indirect Cost

  Institution

Name
Meharry Medical College
Department
Type
DUNS #
041438185
City
Nashville
State
TN
Country
United States
Zip Code
37208

  Publications

Umeukeje, Ebele M; Wild, Marcus G; Maripuri, Saugar et al. (2018) Black Americans' Perspectives of Barriers and Facilitators of Community Screening for Kidney Disease. Clin J Am Soc Nephrol 13:551-559
Vercruysse, Koen; Clark, Astiney; Alatas, Noor et al. (2018) Polysaccharide-mediated synthesis of melanins from serotonin and other 5-hydroxy indoles. Future Sci OA 4:FSO280
Hull, P C; Buchowski, M; Canedo, J R et al. (2018) Childhood obesity prevention cluster randomized trial for Hispanic families: outcomes of the healthy families study. Pediatr Obes 13:686-696
Sanderson, Maureen; Aldrich, Melinda C; Levine, Robert S et al. (2018) Neighbourhood deprivation and lung cancer risk: a nested case-control study in the USA. BMJ Open 8:e021059
Ochieng, Josiah; Nangami, Gladys; Sakwe, Amos et al. (2018) Impact of Fetuin-A (AHSG) on Tumor Progression and Type 2 Diabetes. Int J Mol Sci 19:
Tantawy, Mohammed N; Charles Manning, H; Peterson, Todd E et al. (2018) Translocator Protein PET Imaging in a Preclinical Prostate Cancer Model. Mol Imaging Biol 20:200-204
Burroughs, Andrea Flores; Eluhu, Sylvia; Whalen, Diva et al. (2018) PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus. Cell Physiol Biochem 47:800-816
Ignacio, Rosa Mistica C; Lee, Eun-Sook; Wilson, Andrew J et al. (2018) Chemokine Network and Overall Survival in TP53 Wild-Type and Mutant Ovarian Cancer. Immune Netw 18:e29
Wilkins, Consuelo H (2018) Putting The Person In Personalized Medicine Personalized Medicine: Empowered Patients In The 21st Century? By Barbara Prainsack New York (NY) : NYU Press , 2017 288 pp., $30. Health Aff (Millwood) 37:823-824
Ignacio, Rosa Mistica C; Dong, Yuan-Lin; Kabir, Syeda M et al. (2018) CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. Oncotarget 9:9751-9765

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