Abstract

Prostate cancer (PCa) is a prevailing disease found in African American men, and is the most frequently diagnosed cancer in American men. African American males died of PCa in a 2.39-folder higher rate as compared with Caucasian males, while the average death rate due to all cancers was only 1.34-fold higher between these two races (Cancer Statistics 2010)^?. Surgery, radiation therapy and androgen-deprivation therapy have been developed and applied widely to control PCa;however, prostate cancer patients still died of Castration Resistant Prostate Cancer (CRPC). Molecular signaling pathways contributing to the initiation and progression of PCa;particularly, the mechanism of CRPC growth remain to be elucidated in order to develop efficient strategies for cancer control. Aberrant regulation of Pten-PI3K-Akt pathway, p53 loss and Skp2 activation are commonly found in CRPC. Further investigation on their roles in PCa progression will help us to understand the incidence and mortality rate of PCa, and the disparities among ethnic and racial groups.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163072-03
Application #
8541779
Study Section
Special Emphasis Panel (ZCA1-SRLB-Y)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
3
Fiscal Year
2013
Total Cost
$53,365
Indirect Cost
$24,406

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

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Yang, Yaohua; Cai, Qiuyin; Shu, Xiao-Ou et al. (2018) Prospective study of oral microbiome and colorectal cancer risk in low-income and African American populations. Int J Cancer :
Brown, Shyretha; Tehrani, Shahin; Whalen, Margaret M (2017) Dibutyltin-induced alterations of interleukin 1beta secretion from human immune cells. J Appl Toxicol 37:181-191
Amara, Suneetha; Tiriveedhi, Venkataswarup (2017) The Five Immune Forces Impacting DNA-Based Cancer Immunotherapeutic Strategy. Int J Mol Sci 18:
Selove, Rebecca; Foster, Maya; Wujcik, Debra et al. (2017) Psychosocial concerns and needs of cancer survivors treated at a comprehensive cancer center and a community safety net hospital. Support Care Cancer 25:895-904
Schlundt, David; Briley, Chiquita; Canada, Barbara et al. (2017) Availability of Low-Fat Milk and Produce in Small and Mid-Sized Grocery Stores After 2014 WIC Final Rule Changes, Tennessee. Prev Chronic Dis 14:E70
Sanderson, Maureen; Canedo, Juan R; Khabele, Dineo et al. (2017) Pragmatic trial of an intervention to increase human papillomavirus vaccination in safety-net clinics. BMC Public Health 17:158

Showing the most recent 10 out of 94 publications