The Administrative Core will have eight central goals: (a) facilitating interaction and communication along the participating research groups;(b) forming a repository of information for research resources generated by program investigators available to other project investigators;(c) obtaining constructive criticism from extramural and intramural scientists that may help investigators to obtain their research goals;(d) coordinating Resource sharing to the broad scientific community (i.e. Resource Sharing);(e) providing biostatistical support to all of the projects;(f) performing the reporting tasks required by the NIH;(g) ensuring appropriate approvals (i.e. radiation, human subjects, animal welfare, DNA) are obtained and adhered to;and (h) providing administrative services to the project as a whole. The Core will be directed by Dr. Russell S. Taichman. Support is requested for an individual who will manage the fiscal administration and general program activities. Ms. Stephanie Daignault will provide biostatistical support. These goals will be accomplished by a variety of activities including: Weekly Project Leader meetings Monthly Project Team meetings Annual one-day visits by our External Advisory Board Annual one-day visits with our Internal Advisory Board Biostatistical review of all animal projects prior to initiation of the project.

Public Health Relevance

This TMEN is focused on the mechanisms that regulate dormancy of skeletal metastases in prostate cancer. This core will oversee the operations of the entire Program to ensure that it moves forward in a direction that addresses this important clinical problem.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA163124-04
Application #
8713960
Study Section
Special Emphasis Panel (ZCA1-SRLB-3)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
4
Fiscal Year
2014
Total Cost
$74,324
Indirect Cost
$26,527
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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de Groot, Amber E; Pienta, Kenneth J (2018) Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages. Oncotarget 9:20908-20927
Wu, Amy; Liao, David; Kirilin, Vlamimir et al. (2018) Cancer dormancy and criticality from a game theory perspective. Cancer Converg 2:1
Park, Sun H; Keller, Evan T; Shiozawa, Yusuke (2018) Bone Marrow Microenvironment as a Regulator and Therapeutic Target for Prostate Cancer Bone Metastasis. Calcif Tissue Int 102:152-162
Lee, Eunsohl; Wang, Jingcheng; Jung, Younghun et al. (2018) Reduction of two histone marks, H3k9me3 and H3k27me3 by epidrug induces neuroendocrine differentiation in prostate cancer. J Cell Biochem 119:3697-3705
van der Toom, Emma E; Axelrod, Haley D; de la Rosette, Jean J et al. (2018) Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies. Nat Rev Urol :
Valkenburg, Kenneth C; de Groot, Amber E; Pienta, Kenneth J (2018) Targeting the tumour stroma to improve cancer therapy. Nat Rev Clin Oncol 15:366-381
Chalfin, Heather J; Glavaris, Stephanie A; Malihi, Paymaneh D et al. (2018) Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms. J Urol 199:1494-1501
Decker, A M; Taichman, L S; D'Silva, N J et al. (2018) Periodontal Treatment in Cancer Patients: An Interdisciplinary Approach. Curr Oral Health Rep 5:7-12
Decker, Ann M; Jung, Younghun; Cackowski, Frank C et al. (2017) Sympathetic Signaling Reactivates Quiescent Disseminated Prostate Cancer Cells in the Bone Marrow. Mol Cancer Res 15:1644-1655

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