The pathology core will facilitate research proposed in this grant by collecting, curating, and molecularly annotating human tissue specimens for study. Both fresh-frozen and formalin-fixed paraffin embedded samples will be included. The core will also provide histopathological expertise for the analysis of both human and murine tissue and assist in the development and interpretation of relevant immunohistochemical stains. We foresee the pathology core actively serving the aims of research projects 1 and 2.
| Ozawa, Tatsuya; Arora, Sonali; Szulzewsky, Frank et al. (2018) A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-?B. Cell Rep 23:3787-3797 |
| Kim, Jun Hyun; Grosbart, Malgorzata; Anand, Roopesh et al. (2017) The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression. Cell Rep 18:496-507 |
| Amankulor, Nduka M; Kim, Youngmi; Arora, Sonali et al. (2017) Mutant IDH1 regulates the tumor-associated immune system in gliomas. Genes Dev 31:774-786 |
| Itkin, Tomer; Gómez-Salinero, Jesús María; Rafii, Shahin (2017) Open the gates: vascular neurocrine signaling mobilizes hematopoietic stem and progenitor cells. J Clin Invest 127:4231-4234 |
| Guo, Peipei; Poulos, Michael G; Palikuqi, Brisa et al. (2017) Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression. J Clin Invest 127:4242-4256 |
| Park, Young Bong; Hohl, Marcel; Padjasek, Micha? et al. (2017) Eukaryotic Rad50 functions as a rod-shaped dimer. Nat Struct Mol Biol 24:248-257 |
| Lis, Raphael; Karrasch, Charles C; Poulos, Michael G et al. (2017) Conversion of adult endothelium to immunocompetent haematopoietic stem cells. Nature 545:439-445 |
| Shido, Koji; Chavez, Deebly; Cao, Zhongwei et al. (2017) Platelets prime hematopoietic and vascular niche to drive angiocrine-mediated liver regeneration. Signal Transduct Target Ther 2: |
| Boire, Adrienne; Zou, Yilong; Shieh, Jason et al. (2017) Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis. Cell 168:1101-1113.e13 |
| Badri, H; Pitter, K; Holland, E C et al. (2016) Optimization of radiation dosing schedules for proneural glioblastoma. J Math Biol 72:1301-36 |
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