The IDG Administrative Core (AC) relies on the extensive management experience of the Oprea, Sklar and Simeonov, and also the UNMCMD program and project management infrastructure. We discuss the AC structure and personnel, the composition of an External Target Panel and External Scientific Panel, and the facilitation of communications throughout the Center and with NIH staff. This plan takes into account many years of PI/PD experience with NIH programs involving technology integration, program and project management. The plan addresses ongoing evaluation of software development progress, communications, group meetings and teleconferences, presentation and publication of data, transmission of information, as well as tracking deliverables and milestones, such as through the use of a Gantt chart. Through our participation in BARD, we are accustomed to engagement and monthly meetings with NIH program managers and external scientific review panels regarding the identification and resolution of problems. The decade of experience with the MLPCN has strengthened our ability to successfully collaborate with multiple investigators, both within and outside the United States. Our problem-solving skills, the ability to coordinate, and tele-collaborate are supported by the number of chemical probes, investigator-initiated clinical trials, as well as patented technologies and publications from our team. We have managed consortia (subcontracts) through regular communications such as periodic meetings and conference calls. Documentation of research experiments and their results will be reviewed using extensive experience. The budget process manages research-related travel through approval both at the Center and Institutional levels. The AC partners with UNM on compliance with Federal regulations, policies, and guidelines for human subject research, evaluation of risks and protections, ethical oversight, and data and safety monitoring as appropriate.
The KMC will combine unrelated informational elements from biology, chemistry and clinical sciences, and distill them into knowledge, associating diseases and proteins, to rank proteins for druggability using facts, inferences and predictions. The results, captured in the
| Oprea, Tudor I; Bologa, Cristian G; Brunak, Søren et al. (2018) Unexplored therapeutic opportunities in the human genome. Nat Rev Drug Discov 17:377 |
| Collins, Kyla A L; Stuhlmiller, Timothy J; Zawistowski, Jon S et al. (2018) Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer. Oncotarget 9:15480-15497 |
| Oprea, Tudor I; Bologa, Cristian G; Brunak, Søren et al. (2018) Unexplored therapeutic opportunities in the human genome. Nat Rev Drug Discov 17:317-332 |
| Sinha, Swati; Eisenhaber, Birgit; Jensen, Lars Juhl et al. (2018) Darkness in the Human Gene and Protein Function Space: Widely Modest or Absent Illumination by the Life Science Literature and the Trend for Fewer Protein Function Discoveries Since 2000. Proteomics 18:e1800093 |
| Stathias, Vasileios; Jermakowicz, Anna M; Maloof, Marie E et al. (2018) Drug and disease signature integration identifies synergistic combinations in glioblastoma. Nat Commun 9:5315 |
| Cannon, Daniel C; Yang, Jeremy J; Mathias, Stephen L et al. (2017) TIN-X: target importance and novelty explorer. Bioinformatics 33:2601-2603 |
| Ursu, Oleg; Holmes, Jayme; Knockel, Jeffrey et al. (2017) DrugCentral: online drug compendium. Nucleic Acids Res 45:D932-D939 |
| Nguyen, Dac-Trung; Mathias, Stephen; Bologa, Cristian et al. (2017) Pharos: Collating protein information to shed light on the druggable genome. Nucleic Acids Res 45:D995-D1002 |
| Nelson, Stuart J; Oprea, Tudor I; Ursu, Oleg et al. (2017) Formalizing drug indications on the road to therapeutic intent. J Am Med Inform Assoc 24:1169-1172 |
| Sánchez-Rodríguez, Aminael; Pérez-Castillo, Yunierkis; Schürer, Stephan C et al. (2017) From flamingo dance to (desirable) drug discovery: a nature-inspired approach. Drug Discov Today 22:1489-1502 |
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