The Clinical and Repository Core seeks to facilitate the laboratory investigations of all three Consortium projects, while also benefitting from the management of the Administrative Core and providing opportunities for scientific leadership development in collaboration with the Mentorship Core through the following Specific Aims: 1) To recruit, screen, and enroll into research protocols subjects from Ugandan HIV-positive populations with or at risk for AIDS-Defining malignancies;2) To follow participants prospectively on studies, maintaining close adherence to study procedures;3) To help maintain a robust biospecimen repository to facilitate the study of the natural history of AIDS-defining malignancies in Uganda and to make these specimens available to the laboratories involved in all three program projects;4) To facilitate the collection and analysis of data obtained from participants in clinical research studies to allow for the characterization of the clinical, epidemiologic and medical determinants of response to treatment of AIDS-defining malignancies in Uganda. To achieve these aims, the Core will leverage a well-established translational and clinical research infrastructure that has been built by the collaboration between the Hutchinson Center and the Uganda Cancer Institute. A staff of more than 50 individuals who have all been trained in HIV-associated malignancy research and good clinical and laboratory practice work at the collaboration's research clinic in Kampala, which has studied more than 7,000 participants and currently maintains a biorepository with more than 150,000 specimens from patients with HIV and cancer. The Core will support selected staff to provide specimens and data from patients in ongoing prospective cohort studies with or at risk for Kaposi Sarcoma, non-Hodgkin Lymphoma and invasive cervical cancer. At the same time, trainees in clinical research and laboratory science will be integrated into the Core's activities in collaboration with the Mentorship Core to continue to develop a cadre of outstanding Ugandan investigators to lead future studies in HIV-associated malignancies.

Public Health Relevance

The Clinical Research and Repository Core will support an outstanding infrastructure in Kampala to supply data and biospecimens for translational research studies informing the factors governing the natural history of three AIDS-Defining Cancers in sub-Saharan Africa. These data and specimens will originate from both a well-established biorespository and a research clinic in Kampala with a decade of experience in conducting research studies of patients with HIV and cancer in Uganda

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-RPRB-O (M2))
Program Officer
Dominguez, Geraldina
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Fred Hutchinson Cancer Research Center
United States
Zip Code
Beima-Sofie, Kristin; Wamalwa, Dalton; Maleche-Obimbo, Elizabeth et al. (2018) Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants. AIDS 32:267-270
Coghill, Anna E; Schenk, Jeannette M; Mahkoul, Zeina et al. (2018) Omega-3 decreases IL-6 levels in HIV and human herpesvirus-8 coinfected patients in Uganda. AIDS 32:505-512
Menon, Manoj P; Coghill, Anna; Mutyaba, Innocent O et al. (2018) Association Between HIV Infection and Cancer Stage at Presentation at the Uganda Cancer Institute. J Glob Oncol :1-9
Bender Ignacio, Rachel; Ghadrshenas, Matine; Low, Daniel et al. (2018) HIV Status and Associated Clinical Characteristics Among Adult Patients With Cancer at the Uganda Cancer Institute. J Glob Oncol :1-10
Phipps, Warren; Kansiime, Rachel; Stevenson, Philip et al. (2018) Peer Mentoring at the Uganda Cancer Institute: A Novel Model for Career Development of Clinician-Scientists in Resource-Limited Settings. J Glob Oncol :1-11
Coghill, Anna E; Schenk, Jeanette M; Mahkoul, Zeina et al. (2017) Omega-3 decreases interleukin-6 levels in HIV and HHV-8 co-infected patients: results from a randomized supplementation trial in Uganda. AIDS :
Okuku, Fred; Krantz, Elizabeth M; Kafeero, James et al. (2017) Evaluation of a Predictive Staging Model for HIV-Associated Kaposi Sarcoma in Uganda. J Acquir Immune Defic Syndr 74:548-554
Low, Daniel; Merkel, Emily C; Menon, Manoj et al. (2017) Chemotherapy Use at the End of Life in Uganda. J Glob Oncol 3:711-719
Casper, Corey; Fitzmaurice, Christina (2016) Infection-related cancers: prioritising an important and eliminable contributor to the global cancer burden. Lancet Glob Health 4:e580-1