Core C (Biostatistics &Data Management) provides expert support in the biostatistical aspects of the design, conduct and statistical analysis of research projects generated under the U54 and in the design and operation of database management systems. Core members will 1) work with investigators to select valid observational study designs, 2) design effective database management systems for storing and exporting relevant data, 3) interface closely with the Shared Resources Core, in the design of data collection tools and quality assurance methods, 4) conduct efficient and robust data analyses, create graphs and tables, assist investigators with the preparation of presentations and manuscripts, and consult on the design of subsequent research, and 5) serve as a statistical mentor in the Mentoring/Career Development Core. Core statisticians have extensive experience supporting HIV/AIDS and cancer research of all kinds and have existing collaborations with the Project leaders at their respective institutions. The Core's database programmer has comprehensive experience in developing databases, data queries/quality assurance procedures and data extraction programming to generate statistical analysis-ready files. We are thus highly qualified to provide biostatistics and data management support of the highest quality to the U54 research projects.

Public Health Relevance

Core C (Biostatistics &Data Management) will provide crucial shared resources for biostatistical expertise in the design, conduct and statistical analysis of research projects generated under the U54. Core C will also oversee design and operation of secure centralized database management systems for U54 research studies. Core C will provide services to U54 projects at every stage of the research.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-RPRB-O (M2))
Program Officer
Dominguez, Geraldina
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University of Pennsylvania
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Grover, Surbhi; Bvochora-Nsingo, Memory; Yeager, Alyssa et al. (2018) Impact of Human Immunodeficiency Virus Infection on Survival and Acute Toxicities From Chemoradiation Therapy for Cervical Cancer Patients in a Limited-Resource Setting. Int J Radiat Oncol Biol Phys 101:201-210
Johnson, Lauren G; Armstrong, Allison; Joyce, Caroline M et al. (2018) Implementation strategies to improve cervical cancer prevention in sub-Saharan Africa: a systematic review. Implement Sci 13:28
Tawe, Leabaneng; Grover, Surbhi; Narasimhamurthy, Mohan et al. (2018) Molecular detection of human papillomavirus (HPV) in highly fragmented DNA from cervical cancer biopsies using double-nested PCR. MethodsX 5:569-578
Zetola, Nicola M; Grover, Surbhi; Modongo, Chawangwa et al. (2016) Collision of Three Pandemics: The Coexistence of Cervical Cancer, HIV Infection, and Prior Tuberculosis in the Sub-Saharan Country of Botswana. J Glob Oncol 2:47-50
Ermel, Aaron; Qadadri, Brahim; Tong, Yan et al. (2016) Invasive cervical cancers in the United States, Botswana and Kenya: HPV type distribution and health policy implications. Infect Agent Cancer 11:56
Grover, Surbhi; Raesima, Mmakgomo; Bvochora-Nsingo, Memory et al. (2015) Cervical Cancer in Botswana: Current State and Future Steps for Screening and Treatment Programs. Front Oncol 5:239
Kempkes, Bettina; Robertson, Erle S (2015) Epstein-Barr virus latency: current and future perspectives. Curr Opin Virol 14:138-44