PSOC@Penn Liver Cancer: pre-Malignant Stiffening, Membrane Transduction, & Nuclear Rheology Describe the overall goals and strategies for the Administrative Core. The transdisciplinary nature of Cancer Physics requires efficient and effective interactions across boundaries. The Lead of PSOC@Penn's Admin Core, Discher, has had substantive appointments in all three Schools involved for more than a decade. The experience is therefore in place to exploit Penn's unique, unified campus in order to initiate and grow a successful Center for Cancer Physics. The proposal for this Core has three specific aims.
A first aim i s to hire a Center Administrator who will have many tasks, but a first task is to be webmaster for the PSOC@Penn Portal website with both public and restricted access for non-members and members.
The second aim i s to define structures for the Multi-PI Leadership and Advisory Committee of the proposed Center with the goal of maximizing synergy of Penn's Cancer Physics research efforts.
A third aim i n addressing all of the NIH requirements of the Admin Core is to establish metrics of success for Project/Core/Unit evaluation, and means of rejuvenating the Center when metrics are not met and/or when Pilot Projects succeed. 1

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-TCRB-5 (J1))
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University of Pennsylvania
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Lee, Calvin K; de Anda, Jaime; Baker, Amy E et al. (2018) Multigenerational memory and adaptive adhesion in early bacterial biofilm communities. Proc Natl Acad Sci U S A 115:4471-4476
Nair, Praful R; Alvey, Cory; Jin, Xiaoling et al. (2018) Filomicelles Deliver a Chemo-Differentiation Combination of Paclitaxel and Retinoic Acid That Durably Represses Carcinomas in Liver to Prolong Survival. Bioconjug Chem 29:914-927
Huang, Mo; Wang, Jingshu; Torre, Eduardo et al. (2018) SAVER: gene expression recovery for single-cell RNA sequencing. Nat Methods 15:539-542
Ban, Ehsan; Franklin, J Matthew; Nam, Sungmin et al. (2018) Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces. Biophys J 114:450-461
Smith, Lucas R; Cho, Sangkyun; Discher, Dennis E (2018) Stem Cell Differentiation is Regulated by Extracellular Matrix Mechanics. Physiology (Bethesda) 33:16-25
Holle, Andrew W; Young, Jennifer L; Van Vliet, Krystyn J et al. (2018) Cell-Extracellular Matrix Mechanobiology: Forceful Tools and Emerging Needs for Basic and Translational Research. Nano Lett 18:1-8
Pfeifer, Charlotte R; Xia, Yuntao; Zhu, Kuangzheng et al. (2018) Constricted migration increases DNA damage and independently represses cell cycle. Mol Biol Cell 29:1948-1962
Xia, Yuntao; Ivanovska, Irena L; Zhu, Kuangzheng et al. (2018) Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol 217:3796-3808
Ramakrishnan, N; Bradley, Ryan P; Tourdot, Richard W et al. (2018) Biophysics of membrane curvature remodeling at molecular and mesoscopic lengthscales. J Phys Condens Matter 30:273001
Chen, Gang; Huang, Alexander C; Zhang, Wei et al. (2018) Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature 560:382-386

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