The DFCI PSOC is committed to disseminate current and newly generated knowledge of the evolution, diagnosis and treatment of cancer as well as physical sciences approaches to cancer research. This is the basis for our educational outreach and training initiatives designed to enhance the Center and integrate divergent fields. Scientific experts and seasoned mentors will offer a rich program intended to enhance the interaction and training of physicians and scientists both regionally and at off-site facilities from regularly scheduled seminars to specific working groups. We have designed targeted programs and individualized mentorship for faculty, postdocs, graduate and undergraduate students with an evaluation and enhancement process. Our PSOC Administrator has a dual role as the Educational and Outreach Director and is committed to reassessing the effectiveness of all educational programs offered. The Administrator and PIs will meet on a weekly basis to ensure that goals are being met. As part of our education and training program, we will offer an extensive postdoctoral training program, a graduate course at Harvard University on ?Mathematical Modeling of Cancer?, participation in the Harvard Stem Cell Institute summer internship program, a Junior Investigator Symposium, a seminar series, an annual meeting, two small retreats yearly for our PSOC members, and additional research training opportunities relevant to the PSOC research community. In addition, we have created a comprehensive outreach program targeting diverse populations such as patients, high school students, and the general public. We will offer community lectures, a Research on the Road program, social media campaign, participation in DFCI outreach initiatives, patient lecture series, and host a Women of Science conference. The expected result of our initiatives is the enhancement of professional knowledge with the immediate goal of stimulating new research ideas and outcomes that integrate back into the PSOC framework.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54CA193461-01
Application #
8866715
Study Section
Special Emphasis Panel (ZCA1-TCRB-5 (J1))
Project Start
2015-05-19
Project End
2020-04-30
Budget Start
2015-05-19
Budget End
2016-04-30
Support Year
1
Fiscal Year
2015
Total Cost
$192,932
Indirect Cost
$87,287
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Ozawa, Tatsuya; Arora, Sonali; Szulzewsky, Frank et al. (2018) A De Novo Mouse Model of C11orf95-RELA Fusion-Driven Ependymoma Identifies Driver Functions in Addition to NF-?B. Cell Rep 23:3787-3797
Cimino, Patrick J; Kim, Youngmi; Wu, Hua-Jun et al. (2018) Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma. Genes Dev 32:512-523
Stein, Shayna; Zhao, Rui; Haeno, Hiroshi et al. (2018) Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients. PLoS Comput Biol 14:e1005924
Hinohara, Kunihiko; Wu, Hua-Jun; Vigneau, Sébastien et al. (2018) KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance. Cancer Cell 34:939-953.e9
Smith, Zachary D; Shi, Jiantao; Gu, Hongcang et al. (2017) Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer. Nature 549:543-547
Campbell, Peter T; Rebbeck, Timothy R; Nishihara, Reiko et al. (2017) Proceedings of the third international molecular pathological epidemiology (MPE) meeting. Cancer Causes Control 28:167-176
Temko, Daniel; Cheng, Yu-Kang; Polyak, Kornelia et al. (2017) Mathematical Modeling Links Pregnancy-Associated Changes and Breast Cancer Risk. Cancer Res 77:2800-2809
Malone, Clare F; Emerson, Chloe; Ingraham, Rachel et al. (2017) mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors. Cancer Discov 7:1450-1463
Chakrabarti, Shaon; Michor, Franziska (2017) Pharmacokinetics and Drug Interactions Determine Optimum Combination Strategies in Computational Models of Cancer Evolution. Cancer Res 77:3908-3921
Yu, Vionnie W C; Yusuf, Rushdia Z; Oki, Toshihiko et al. (2017) Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells. Cell 168:944-945

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