? ADMINISTRATIVE CORE Cornell University will be the lead institution of our Center on the Physics of Cancer Metabolism that constitutes a multi-institutional effort involving 20 key personnel from Cornell University Ithaca, Weill Cornell Medicine (WCM), Memorial Sloan Kettering Cancer Center (MSKCC), University of Texas MD Anderson Cancer Center, University of California ? San Francisco, and Purdue University. The Administrative Core team will be responsible for organizing and providing resources for effective management and oversight of these individual sites. Given our focus on collaboration, we will use a Multiple PI Leadership approach drawing on the physical sciences and cancer biology expertise of both PIs as well as their respective home institutions. Guidance to the PIs will be provided through the Center Advisory Committee. Furthermore, a Center Administrator will manage day-to-day activities, including subcontracts with our partner institutions and all scientific, administrative, budgetary, and operational aspects of the Center. The overall goal of the Administrative Core will be to guarantee effective administrative and organizational capabilities both within our Center and with the broader Physical Sciences Oncology Network (PSON). This goal will be accomplished through 3 specific aims.
Aim 1 : To manage and effectively deploy the Center's resources to advance transdisciplinary physical sciences research, training, and outreach.
Aim 2 : To enhance the exchange of information and ideas among all Center researchers as well as with the PSON.
Aim 3 : To establish Committees for Center guidance and institute appropriate infrastructure and processes for transparent, effective, and iterative evaluation of all Center activities. The Administrative Core will synergize with all components of the Center to ensure successful integration of Projects and Cores, the Education and Outreach Unit, and research performed through Pilot and Transnetwork Projects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA210184-04
Application #
9748458
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2019-08-01
Budget End
2020-07-31
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Cornell University
Department
Type
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
van Helvert, Sjoerd; Storm, Cornelis; Friedl, Peter (2018) Mechanoreciprocity in cell migration. Nat Cell Biol 20:8-20
Beunk, Lianne; Brown, Kari; Nagtegaal, Iris et al. (2018) Cancer invasion into musculature: Mechanics, molecules and implications. Semin Cell Dev Biol :
Lourenço, Bianca N; Springer, Nora L; Ferreira, Daniel et al. (2018) CD44v6 increases gastric cancer malignant phenotype by modulating adipose stromal cell-mediated ECM remodeling. Integr Biol (Camb) 10:145-158
Elacqua, Joshua J; McGregor, Alexandra L; Lammerding, Jan (2018) Automated analysis of cell migration and nuclear envelope rupture in confined environments. PLoS One 13:e0195664
Yadav, Sandeep Kumar; Feigelson, Sara W; Roncato, Francesco et al. (2018) Frontline Science: Elevated nuclear lamin A is permissive for granulocyte transendothelial migration but not for motility through collagen I barriers. J Leukoc Biol 104:239-251
Takai, Ken; Drain, Allison P; Lawson, Devon A et al. (2018) Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev 32:244-257
DelNero, Peter; Hopkins, Benjamin D; Cantley, Lewis C et al. (2018) Cancer metabolism gets physical. Sci Transl Med 10:
Northcott, Josette M; Dean, Ivory S; Mouw, Janna K et al. (2018) Feeling Stress: The Mechanics of Cancer Progression and Aggression. Front Cell Dev Biol 6:17
Druso, Joseph E; Fischbach, Claudia (2018) Biophysical Properties of Extracellular Matrix: Linking Obesity and Cancer. Trends Cancer 4:271-273
Huang, Qingqiu; Stalnecker, Clint; Zhang, Chengliang et al. (2018) Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J Biol Chem 293:3535-3545

Showing the most recent 10 out of 46 publications