Abstract

Central to NEPTUNE's goals for facilitating translational science in Nephrotic Syndrome (NS) is the maintenance of an infrastructure and funding opportunities that encourages investigators with diverse interests and expertise to use NEPTUNE's intellectual resources, observational clinical data, biospecimens, digital pathology archive, and derived data sets. In the renewal proposal, NEPTUNE plans to continue and expand on the remarkable success of its Pilot and Ancillary Studies Program (PAS). NEPTUNE's goal of accelerating glomerular disease research by being inclusive of diverse scientific interests has been well served by the PAS during the past nine years as the network's data and biobank resources have matured. A steadily increasing trend of use of these resources are evident by the volume of talks, papers, and funded proposals from a large pool of investigators inside and outside the network. By its close association with NephCure Kidney International Foundation (NKI), a leading glomerular disease advocacy foundation, NEPTUNE has funded 10 pilot projects and processed 112 ancillary study proposals during the past nine years. Remarkably, 32 (30%) of these 112 ancillary study committee-approved projects received support external to NEPTUNE.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54DK083912-12
Application #
10017217
Study Section
Special Emphasis Panel (ZTR1)
Project Start
2009-09-08
Project End
2024-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
12
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Park, Sun-Ji; Kim, Yeawon; Chen, Ying Maggie (2018) Endoplasmic reticulum stress and monogenic kidney diseases in precision nephrology. Pediatr Nephrol :
Miyata, Kana N; Nast, Cynthia C; Dai, Tiane et al. (2018) Renal matrix Gla protein expression increases progressively with CKD and predicts renal outcome. Exp Mol Pathol 105:120-129
Grayson, Peter C; Eddy, Sean; Taroni, Jaclyn N et al. (2018) Metabolic pathways and immunometabolism in rare kidney diseases. Ann Rheum Dis 77:1226-1233
Czerniecki, Stefan M; Cruz, Nelly M; Harder, Jennifer L et al. (2018) High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping. Cell Stem Cell 22:929-940.e4
Zee, Jarcy; Hodgin, Jeffrey B; Mariani, Laura H et al. (2018) Reproducibility and Feasibility of Strategies for Morphologic Assessment of Renal Biopsies Using the Nephrotic Syndrome Study Network Digital Pathology Scoring System. Arch Pathol Lab Med 142:613-625
Mariani, Laura H; Martini, Sebastian; Barisoni, Laura et al. (2018) Interstitial fibrosis scored on whole-slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies. Nephrol Dial Transplant 33:310-318
Mitrofanova, Alla; Molina, Judith; Varona Santos, Javier et al. (2018) Hydroxypropyl-?-cyclodextrin protects from kidney disease in experimental Alport syndrome and focal segmental glomerulosclerosis. Kidney Int 94:1151-1159
Troost, Jonathan P; Trachtman, Howard; Nachman, Patrick H et al. (2018) An Outcomes-Based Definition of Proteinuria Remission in Focal Segmental Glomerulosclerosis. Clin J Am Soc Nephrol 13:414-421
Nair, Viji; Komorowsky, Claudiu V; Weil, E Jennifer et al. (2018) A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome. Kidney Int 93:439-449
Zhong, Fang; Chen, Zhaohong; Zhang, Liwen et al. (2018) Tyro3 is a podocyte protective factor in glomerular disease. JCI Insight 3:

Showing the most recent 10 out of 76 publications