; Although state-of-the-art CT provides accurate sub-millimeter details of the size and location of renal stones and separation of uric acid and non-uric acid stones, current routine clinical image analysis does not provide a comprehensive tool to quantitatively assess stone composition, volume, morphology and fragility, or to detect precursor lesions and trace elements related to stone formation. We have demonstrated that the novel algorithms developed in our lab during the initial funding period of our first O'Brien Center grant are able to separate eight common types of renal stones into five groups in an anthropomorphic phantom under clinical conditions, and into four groups in patients. In patients, we demonstrated an overall accuracy of 79.1%. We have also demonstrated the ability to accurately measure stone volume and surface morphology. In Project 1 of the current proposal, we will develop and validate tools to quantify interior stone morphology and use our quantitative measurements of stone composition, volume, surface and interior morphology to predict stone fragility. Thus, CT imaging, which is the predominant clinical tool used to diagnose and stage renal stones, can provide a much richer source of important clinical and research information when dual-energy data are acquired and quantitative analysis techniques used. The Imaging Core will provide five key functions in support of this O'Brien Urology Cooperative Research Center. These functions will directly support Projects 1, 2, and 3, and may be of value for pilot projects initiated during later years of the Center's activities. Additionally, the functions may be of considerable value to extramural researchers in the field of nephrolithiasis, including 1) Dual-energy CT scanning of ex-vivo specimens or patients; 2) Dual-energy CT attenuation, volume and morphology analyses; 3) Spectral CT scanning of ex-vivo specimens; 4) Coordination of micro-CT scanning and fragility testing with Dr. Jim Williams;and 5) Coordination of neutron activation analysis with Dr. Xin Liu.

Public Health Relevance

The Imaging Core is equipped with state of the art CT scanning technology, image processing computers and algorithms. This core provides a rich opportunity for multi-disciplinary research and brings the tremendous advances in imaging science of the last decade into the field of Nephrolithiasis research. The mission of the Imaging Core is to provide comprehensive non-invasive assessment of renal stones.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-9)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mayo Clinic, Rochester
United States
Zip Code
Moen, Taylor; Ferrero, Andrea; McCollough, Cynthia (2018) Robustness of Textural Features to Predict Stone Fragility Across Computed Tomography Acquisition and Reconstruction Parameters. Acad Radiol :
Abd El-Salam, Mohamed; Bastos, Jairo Kenupp; Han, Jing Jing et al. (2018) The Synthesized Plant Metabolite 3,4,5-Tri-O-Galloylquinic Acid Methyl Ester Inhibits Calcium Oxalate Crystal Growth in a Drosophila Model, Downregulates Renal Cell Surface Annexin A1 Expression, and Decreases Crystal Adhesion to Cells. J Med Chem 61:1609-1621
Sivaguru, Mayandi; Saw, Jessica J; Williams Jr, James C et al. (2018) Geobiology reveals how human kidney stones dissolve in vivo. Sci Rep 8:13731
Shah, Ronak Jagdeep; Lieske, John C (2018) Inching toward a Greater Understanding of Genetic Hypercalciuria: The Role of Claudins. Clin J Am Soc Nephrol 13:1460-1462
Ruetten, Hannah; Wegner, Kyle A; Romero, Michael F et al. (2018) Prostatic collagen architecture in neutered and intact canines. Prostate 78:839-848
Marcus, Roy P; Fletcher, Joel G; Ferrero, Andrea et al. (2018) Detection and Characterization of Renal Stones by Using Photon-Counting-based CT. Radiology 289:436-442
Ferrero, Andrea; Gutjahr, Ralf; Halaweish, Ahmed F et al. (2018) Characterization of Urinary Stone Composition by Use of Whole-body, Photon-counting Detector CT. Acad Radiol 25:1270-1276
Vaughan, Lisa E; Enders, Felicity T; Lieske, John C et al. (2018) Predictors of Symptomatic Kidney Stone Recurrence After the First and Subsequent Episodes. Mayo Clin Proc :
Kittanamongkolchai, Wonngarm; Vaughan, Lisa E; Enders, Felicity T et al. (2018) The Changing Incidence and Presentation of Urinary Stones Over 3 Decades. Mayo Clin Proc 93:291-299
Dhondup, Tsering; Kittanamongkolchai, Wonngarm; Vaughan, Lisa E et al. (2018) Risk of ESRD and Mortality in Kidney and Bladder Stone Formers. Am J Kidney Dis 72:790-797

Showing the most recent 10 out of 100 publications