/ The mission of the Animal Modeling Core (AMC) is to provide research groups within the YCCEH and the larger scientific community access to the latest technologies for hematologic studies in animal models. In vivo studies allow researchers to ask questions about the function of molecules, cell populations, and tissues within the relevant spatial and temporal contexts. The YCCEH will continue to provide scientists training and facilitate research in mouse models of hematologic diseases. Importantly, the AMC will continue to develop and propagate the most innovative humanized mouse models for the study of human hematopoiesis and diseases thereof with the goal to overcome major shortcomings of current models. The AMC consists of two cores, the Humanized Mouse Core (HMC) and the Murine Stem Cell Transplantation Core (mSCTC). The Animal Modeling Core will be directed by Dr Richard Flavell, Sterling Professor of Immunobiology and co-directed by Dr. Stephanie Halene, Associate Professor and Acting Section Chief of Hematology. The HMC will offer expertise, technical assistance, and mice for human-into-mouse xenotransplantation studies. The mSCTC will offer training and technical assistance in the study of hematopoiesis and benign hematologic questions in mice. The Humanized Mouse Core will facilitate human-into-mouse xenotransplantation studies into immunodeficient mice. As a unique feature the Yale HMC will offer hematology researchers access to novel humanized immunodeficient mice optimized to support human hematopoietic stem cells, trilineage hematopoiesis, mature myeloid cells, red cells and platelets in circulation, and a functional human immune system. The Murine Stem Cell Transplantation Core will provide technical expertise in the study of hematologic questions in mice. The mSCTC will offer training and expertise for the study of hematopoiesis and hematologic diseases in mice using hematopoietic cell transplantation and functional assays. The Animal Modeling Core will be an integral part of the YCCEH. It will provide Hematology researchers with access to state-of-the-art technologies for in vivo studies of hematopoiesis and hematologic diseases. It will provide teaching, expertise, and resources in an economical way. Its cores will support basic science as well as translational studies, key to understanding and cure of hematologic diseases.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
New Haven
United States
Zip Code
Xavier-Ferrucio, Juliana; Ricon, Lauremília; Vieira, Karla et al. (2018) Hematopoietic defects in response to reduced Arhgap21. Stem Cell Res 26:17-27
Ricciardi, Adele S; Bahal, Raman; Farrelly, James S et al. (2018) In utero nanoparticle delivery for site-specific genome editing. Nat Commun 9:2481
Liang, Yang; Tebaldi, Toma; Rejeski, Kai et al. (2018) SRSF2 mutations drive oncogenesis by activating a global program of aberrant alternative splicing in hematopoietic cells. Leukemia 32:2659-2671
Weinstein, Jason S; Laidlaw, Brian J; Lu, Yisi et al. (2018) STAT4 and T-bet control follicular helper T cell development in viral infections. J Exp Med 215:337-355
Gupta, Abhishek K; Murthy, Tushar; Paul, Kiran V et al. (2018) Degenerate minigene library analysis enables identification of altered branch point utilization by mutant splicing factor 3B1 (SF3B1). Nucleic Acids Res :
Rahman, Nur-Taz; Schulz, Vincent P; Wang, Lin et al. (2018) MRTFA augments megakaryocyte maturation by enhancing the SRF regulatory axis. Blood Adv 2:2691-2703
Xavier-Ferrucio, Juliana; Krause, Diane S (2018) Concise Review: Bipotent Megakaryocytic-Erythroid Progenitors: Concepts and Controversies. Stem Cells 36:1138-1145
Glogowska, Edyta; Schneider, Eve R; Maksimova, Yelena et al. (2017) Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis. Blood 130:1845-1856
Pan, Wen; Zhu, Shu; Qu, Kun et al. (2017) The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression. Immunity 47:284-297.e5
Swartz, Kelsey L; Wood, Scott N; Murthy, Tushar et al. (2017) E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol 37:

Showing the most recent 10 out of 19 publications