The Metabolomics Core will provide analytic measurements of biologic building blocks, amino acids, nucleotides, lipids and carbohydrates to investigators of the Center for Iron and Heme Disorders (CIHD). Metabolomics is the unbiased survey of metabolites found within a tissue, biological fluid, organism, culture or other biological source. Currently metabolomics is a comparative science; typically an analysis is performed to identify the differences found between biological samples that have been subjected to a treatment or condition. This can be a genetic mutation, drug treatment or environmental constraint. No one method is fully capable of completely profiling the metabolome of a cell or tissue. To maximize the number of metabolites observed, the Core is equipped with three chemical analysis platforms, Gas Chromatography-Mass Spectrometry, Liquid Chromatography-Mass Spectrometry, and Nuclear Magnetic Resonance spectroscopy. The research base of the CIHD focuses on questions that can easily be addressed with these services. The staff of the proposed Metabolomics Core will assist investigators in training sessions for sample preparation, equipment use and analysis. Program staff will also assist users in preparation of materials for publications and presentations within the CIHD and externally to national and international meetings.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-R (M4)S)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Utah
Salt Lake City
United States
Zip Code
Tsushima, Kensuke; Bugger, Heiko; Wende, Adam R et al. (2018) Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission. Circ Res 122:58-73
Burch, Joseph S; Marcero, Jason R; Maschek, John Alan et al. (2018) Glutamine via ?-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Blood 132:987-998
Ellipilli, Satheesh; Phillips, John D; Heemstra, Jennifer M (2018) Synthesis of comb-shaped DNA using a non-nucleosidic branching phosphoramidite. Org Biomol Chem 16:4659-4664
Ward, Diane M; Chen, Opal S; Li, Liangtao et al. (2018) Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis. J Biol Chem 293:10782-10795
Winge, Dennis R (2018) Filling the mitochondrial copper pool. J Biol Chem 293:1897-1898
Meznarich, Jessica A; Draper, Lauren; Christensen, Robert D et al. (2018) Fetal presentation of congenital dyserythropoietic anemia type 1 with novel compound heterozygous CDAN1 mutations. Blood Cells Mol Dis 71:63-66
Liu, Ka-Cheuk; Leuckx, Gunter; Sakano, Daisuke et al. (2018) Inhibition of Cdk5 Promotes ?-Cell Differentiation From Ductal Progenitors. Diabetes 67:58-70
Li, Liangtao; Ward, Diane M (2018) Iron toxicity in yeast: transcriptional regulation of the vacuolar iron importer Ccc1. Curr Genet 64:413-416
Yien, Yvette Y; Shi, Jiahai; Chen, Caiyong et al. (2018) FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity. J Biol Chem 293:19797-19811
Choby, Jacob E; Buechi, Hanna B; Farrand, Allison J et al. (2018) Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus. MBio 9:

Showing the most recent 10 out of 48 publications