Abstract

Purpose of Bridging Project (Abstract): This Bridging Project proposes new research that extends our efforts to understand how fucosylation controls selectin-dependent leukocyte adhesion and leukocyte trafficking. This project will focus on the selectin of carbohydrate binding proteins (CBPs). The Project addresses the two following Specific Aims: For each CBP (the selectins for this Bridging Project), identify the ligands on biologically relevant cell types and determine the carbohydrate structure(s) that mediate(s) CBP binding. Determine the extent to which regulation of glycosylation modulates the expression of CBP ligands and controls CBP function.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54GM062116-02S1
Application #
6655295
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Peng, Wenjie; Bouwman, Kim M; McBride, Ryan et al. (2018) Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation. J Virol 92:
Sadana, Pooja; Geyer, Rebecca; Pezoldt, Joern et al. (2018) The invasin D protein from Yersinia pseudotuberculosis selectively binds the Fab region of host antibodies and affects colonization of the intestine. J Biol Chem 293:8672-8690
Nemanichvili, Nikoloz; Tomris, Ilhan; Turner, Hannah L et al. (2018) Fluorescent Trimeric Hemagglutinins Reveal Multivalent Receptor Binding Properties. J Mol Biol :
Yang, Hua; Carney, Paul J; Chang, Jessie C et al. (2018) Structural and Molecular Characterization of the Hemagglutinin from the Fifth Epidemic Wave A(H7N9) Influenza Viruses. J Virol :
van Eijk, Martin; Rynkiewicz, Michael J; Khatri, Kshitij et al. (2018) Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. J Biol Chem 293:10646-10662
Griffiths, James S; Thompson, Aiysha; Stott, Matthew et al. (2018) Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases. FASEB J 32:3385-3397
de Vries, Robert P; Tzarum, Netanel; Peng, Wenjie et al. (2017) A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors. EMBO Mol Med 9:1314-1325
Lubkowski, Jacek; Durbin, Sarah V; Silva, Mariana C C et al. (2017) Structural analysis and unique molecular recognition properties of a Bauhinia forficata lectin that inhibits cancer cell growth. FEBS J 284:429-450
Scheepers, Cathrine; Chowdhury, Sudipa; Wright, W Shea et al. (2017) Serum glycan-binding IgG antibodies in HIV-1 infection and during the development of broadly neutralizing responses. AIDS 31:2199-2209
Schneider, Christoph; Wicki, Simone; Graeter, Stefanie et al. (2017) IVIG regulates the survival of human but not mouse neutrophils. Sci Rep 7:1296

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