The Core is comprised of two components, Information Dissemination and Information Coordination. The goal of the former is to disseminate information on technology, scientific findings and methodologies as rapidly, yet responsibly, as possible. The goal of the latter is to provide hardware and software infrastructure to manage, analyze, and distribute the sequence, expression, and structural information, and information on Cell Migration activities, produced by the Cell Migration Consortium. The Consortium's web site (www.cellmigration.org) is the major forum for information transfer. It has existed in three editions. The initial web site announced the Consortium and outlined its organization, objectives, approaches, and activities. It also contained material of interest to the general migration community including meeting announcements, an introduction to Cell Migration for the general public, and initial Consortium accomplishments. The second edition was launched as the Consortium began to produce significant data, technologies, and other products. The activities section was expanded greatly to include detailed descriptions of the Consortium activities and approaches for each initiative, descriptions on data release and collaboration policies, lists of completed, ongoing and planned activities, contact personnel, and the products of the initiatives. The latter takes several forms depending on the initiative. For some, it could be a list of publications, software, or protocols. For others, e.g., the proteomics and discovery initiatives, it includes data sets. Finally, there are lists of pertinent, non Consortium generated resources, e.g., an inclusive list of biosensors or phosphorylation specific antibodies for the Biosensor Initiative. All of these data were coordinated and linked to the Cell Migration Knowledgebase (CMKB, see below). The most recent edition is a result of collaboration with the Nature Publishing Group (NPG), the goal being to bring our products to the attention of the broadest possible audience, on the one hand, and to provide a resource for the field as a whole, by presenting not only Consortium generated information, but information about cell migration that goes beyond the Consortium.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM064346-09
Application #
7906668
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
9
Fiscal Year
2009
Total Cost
$363,390
Indirect Cost
Name
University of Virginia
Department
Type
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Hu, Guiqing; Taylor, Dianne W; Liu, Jun et al. (2018) Identification of interfaces involved in weak interactions with application to F-actin-aldolase rafts. J Struct Biol 201:199-209
Kubow, Kristopher E; Shuklis, Victoria D; Sales, Dominic J et al. (2017) Contact guidance persists under myosin inhibition due to the local alignment of adhesions and individual protrusions. Sci Rep 7:14380
Gallegos, Lisa Leon; Ng, Mei Rosa; Sowa, Mathew E et al. (2016) A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for ?-catenin. Sci Rep 6:27114
Al-Dimassi, Saleh; Salloum, Gilbert; Saykali, Bechara et al. (2016) Targeting the MAP kinase pathway in astrocytoma cells using a recombinant anthrax lethal toxin as a way to inhibit cell motility and invasion. Int J Oncol 48:1913-20
Juanes-Garcia, Alba; Chapman, Jessica R; Aguilar-Cuenca, Rocio et al. (2015) A regulatory motif in nonmuscle myosin II-B regulates its role in migratory front-back polarity. J Cell Biol 209:23-32
Gao, Runchi; Zhao, Siwei; Jiang, Xupin et al. (2015) A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum. Sci Signal 8:ra50
Dai, Aguang; Ye, Feng; Taylor, Dianne W et al. (2015) The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand. J Biol Chem 290:27168-75
Márquez, G; Pinto, A; Alamo, L et al. (2014) A method for 3D-reconstruction of a muscle thick filament using the tilt series images of a single filament electron tomogram. J Struct Biol 186:265-72
Zgheib, Perla; Daher, Costantine F; Mroueh, Mohamad et al. (2014) Daucus carota Pentane/Diethyl Ether Fraction Inhibits Motility and Reduces Invasion of Cancer Cells. Chemotherapy 60:302-9
Hinde, Elizabeth; Yokomori, Kyoko; Gaus, Katharina et al. (2014) Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation. Sci Rep 4:4219

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