Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM074929-05
Application #
7903175
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
5
Fiscal Year
2009
Total Cost
$472,348
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Molnar, Kathleen S; Bonomi, Massimiliano; Pellarin, Riccardo et al. (2014) Cys-scanning disulfide crosslinking and bayesian modeling probe the transmembrane signaling mechanism of the histidine kinase, PhoQ. Structure 22:1239-1251
Jiang, Xiaoxu; Villafuerte, Maria Katerina R; Andersson, Magnus et al. (2014) Galactoside-binding site in LacY. Biochemistry 53:1536-43
Geier, Ethan G; Schlessinger, Avner; Fan, Hao et al. (2013) Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1. Proc Natl Acad Sci U S A 110:5480-5
Wittwer, Matthias B; Zur, Arik A; Khuri, Natalia et al. (2013) Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J Med Chem 56:781-795
Schlessinger, Avner; Khuri, Natalia; Giacomini, Kathleen M et al. (2013) Molecular modeling and ligand docking for solute carrier (SLC) transporters. Curr Top Med Chem 13:843-56
Jiang, Xiaoxu; Driessen, Arnold J M; Feringa, Ben L et al. (2013) The periplasmic cavity of LacY mutant Cys154?Gly: how open is open? Biochemistry 52:6568-74
Schlessinger, A; Yee, S W; Sali, A et al. (2013) SLC classification: an update. Clin Pharmacol Ther 94:19-23
Lasker, Keren; Velázquez-Muriel, Javier A; Webb, Benjamin M et al. (2012) Macromolecular assembly structures by comparative modeling and electron microscopy. Methods Mol Biol 857:331-50
Zhou, Yonggang; Jiang, Xiaoxu; Kaback, H Ronald (2012) Role of the irreplaceable residues in the LacY alternating access mechanism. Proc Natl Acad Sci U S A 109:12438-42
Andersson, Magnus; Bondar, Ana-Nicoleta; Freites, J Alfredo et al. (2012) Proton-coupled dynamics in lactose permease. Structure 20:1893-904

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