Abstract

Public Health Relevance

Proteins embedded in membranes are abundant (20-30% of proteins in any organism) and they perform some of the most essential of activities in biology. Their importance for biomedicine is evident as they are the molecular targets of more than 40% of all FDA-approved drugs. Yet, because membrane proteins present severe challenges for biophysical study, membrane proteins currently constitute less than 1% of known atomic-level structures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54GM095315-01
Application #
8151942
Study Section
Special Emphasis Panel (ZGM1-CBB-3 (MP))
Project Start
2010-09-30
Project End
2015-06-30
Budget Start
2010-09-30
Budget End
2011-06-30
Support Year
1
Fiscal Year
2010
Total Cost
$2,048,677
Indirect Cost

  Institution

Name
New York Structural Biology Center
Department
Type
DUNS #
011191520
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Assur Sanghai, Zahra; Liu, Qun; Clarke, Oliver B et al. (2018) Structure-based analysis of CysZ-mediated cellular uptake of sulfate. Elife 7:
Su, Min; Gao, Feng; Yuan, Qi et al. (2017) Structural basis for conductance through TRIC cation channels. Nat Commun 8:15103
Dufrisne, Meagan Belcher; Petrou, Vasileios I; Clarke, Oliver B et al. (2017) Structural basis for catalysis at the membrane-water interface. Biochim Biophys Acta Mol Cell Biol Lipids 1862:1368-1385
Scaglione, Antonella; Montemiglio, Linda Celeste; Parisi, Giacomo et al. (2017) Subcellular localization of the five members of the human steroid 5?-reductase family. Biochim Open 4:99-106
Kalathur, Ravi C; Panganiban, Marinela; Bruni, Renato (2016) High-Throughput Baculovirus Expression System for Membrane Protein Production. Methods Mol Biol 1432:187-202
Bernhofer, Michael; Kloppmann, Edda; Reeb, Jonas et al. (2016) TMSEG: Novel prediction of transmembrane helices. Proteins 84:1706-1716
McCoy, Jason G; Ren, Zhenning; Stanevich, Vitali et al. (2016) The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport. Structure 24:956-64
Hendrickson, Wayne A (2016) Atomic-level analysis of membrane-protein structure. Nat Struct Mol Biol 23:464-7
des Georges, Amédée; Clarke, Oliver B; Zalk, Ran et al. (2016) Structural Basis for Gating and Activation of RyR1. Cell 167:145-157.e17
Chen, Yunting; Clarke, Oliver B; Kim, Jonathan et al. (2016) Structure of the STRA6 receptor for retinol uptake. Science 353:

Showing the most recent 10 out of 46 publications