Achieving the goal of the IDeA-CTR Program to improve our nation's health requires that the research establishment recruit and effectively train scientists and physicians to collaboratively conduct cutting edge clinical and translational biomedical research. Accordingly, the mission of the Northern New England Clinical and Translational Research Network's Professional Development Core (PDC) is to develop robust mentoring programs and novel, effective educational offerings that increase the number and the productivity of those engaged in clinical and translational research in our region. Several important principles will guide the development of the PDC. These will include: (i) a strong focus on developing educational offerings and mentoring programs that take advantage of the diverse strengths of our institutions and their faculty; (ii) the development of specific educational programs and resources that prioritize and actively ?catalyze?, team science, thus enhancing our ability to initiate and manage complex multidisciplinary and multi-institutional translational research projects; (iii) the development of innovative team-based ?mosaic? mentoring models that recognize the complex mix of professional expectations placed on clinical investigators; (iv) a commitment to bringing more practicing clinicians into the investigative arena to take advantage of their clinical expertise and access to potential research subjects; and (v) the recognition that our education and mentorship programs must facilitate a bi-directional flow of ideas and information within our institutions and our region. The PDC will accomplish these goals by addressing the following specific aims: 1) to enhance the capabilities of basic scientists and collaborating physicians to conceive, participate in and manage multidisciplinary and bi- directional bench-to-bedside translational research projects; 2) to develop flexible, but rigorous and coordinated educational and training programs to enhance the research competency and participation of clinicians based within varied practice settings and disciplines and with a diverse set of professional goals; 3) to take advantage of the rich supply of mentors at our differing institutions, so as to develop a novel, team- based, mosaic mentorship model that provides guidance and enduring support to mentees with diverse needs and professional goals in order to actively facilitate their success; and 4) to develop a unique certificate program for training PhD and masters level scientists to become clinical and translational research catalysts or community practice-based research catalysts as a defined career path to enhance the national capacity for conducting clinical and translational research. Achieving these specific aims will strongly enhance our ability to foster collaborative, multidisciplinary clinical and translational biomedical research across Northern New England.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54GM115516-01A1
Application #
9361852
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Maine Medical Center
Department
Type
DUNS #
071732663
City
Portland
State
ME
Country
United States
Zip Code
04102
Reifsnyder, Peter C; Ryzhov, Sergey; Flurkey, Kevin et al. (2018) Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Leprdb mice. Ann N Y Acad Sci 1418:106-117
Peterson, Sarah M; Turner, Jacqueline E; Harrington, Anne et al. (2018) Notch2 and Proteomic Signatures in Mouse Neointimal Lesion Formation. Arterioscler Thromb Vasc Biol 38:1576-1593
Farrell, Mariah L; Reagan, Michaela R (2018) Soluble and Cell-Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma. Front Endocrinol (Lausanne) 9:218
Farina, Nicholas H; Zingiryan, Areg; Vrolijk, Michael A et al. (2018) Nanoparticle-based targeted cancer strategies for non-invasive prostate cancer intervention. J Cell Physiol 233:6408-6417
Ryzhov, Sergey; Robich, Michael P; Roberts, Daniel J et al. (2018) ErbB2 promotes endothelial phenotype of human left ventricular epicardial highly proliferative cells (eHiPC). J Mol Cell Cardiol 115:39-50
Yang, Xuehui; Gong, Yan; He, Qing et al. (2018) Loss of Spry1 attenuates vascular smooth muscle proliferation by impairing mitogen-mediated changes in cell cycle regulatory circuits. J Cell Biochem 119:3267-3279
Tracy, Kirsten M; Tye, Coralee E; Page, Natalie A et al. (2018) Selective expression of long non-coding RNAs in a breast cancer cell progression model. J Cell Physiol 233:1291-1299
Fairfield, Heather; Falank, Carolyne; Harris, Elizabeth et al. (2018) The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis. J Cell Physiol 233:1156-1167
Mistry, Swaroop D; Woods, Gina N; Sigurdsson, Sigurdur et al. (2018) Sex hormones are negatively associated with vertebral bone marrow fat. Bone 108:20-24
Stohn, J P; Martinez, M E; Zafer, M et al. (2018) Increased aggression and lack of maternal behavior in Dio3-deficient mice are associated with abnormalities in oxytocin and vasopressin systems. Genes Brain Behav 17:23-35

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