The mission of the Northern New England Clinical and Translational Research (NNE-CTR) Network is to develop and sustain a clinical and translational research infrastructure that supports improvement in rural and community health for inhabitants in the IDeA states of Maine, New Hampshire and Vermont. This goal will be accomplished through complementary and synergistic collaborations of investigators in two lead institutions, Maine Medical Center (a member of the MaineHealth System) and the University of Vermont ( with the University of Vermont Health Network ), one participating institution, the University of Southern Maine, and two collaborating organizations, the Dartmouth SYNERGY Clinical and Translational Science Institute and the Dartmouth Primary Care Cooperative Research Network (Dartmouth CO-OP). The Northeast has the largest percentage of residents over 65 years of age, and while NNE-CTR will support clinical and translational studies of all types, our efforts will emphasize health problems endemic in the rural populations of northern New England, including cancer, cardiovascular disease, and substance abuse, as well as the barriers that compromise rural health care delivery. The members of our proposed network have a long history of collaboration, providing a solid platform for the proposed network. To accomplish these goals, NNE-CTR proposes four specific aims: 1) improve the infrastructure and support for clinical and translational research in Maine, New Hampshire and Vermont; 2) increase translational and clinical research capacity and efficacy by establishing collaborative and synergistic transdisciplinary research partnerships among the NNE-CTR institutions, aided by a vigorous Pilot Projects program; 3) establish innovative training, mentoring and professional development programs to develop clinical and translational scientists at the NNE-CTR institutions; and 4) provide the infrastructure to support community practices and practice-based primary care research networks, particularly in rural areas, to engage clinical, community, public health and other stakeholders in the development and conduct of research relevant to the clinical and population health needs of northern New England. To achieve these aims, NNE-CTR will establish the following Key Component Activities: Administrative Core; Pilot Projects Program; Professional Development Core; Clinical Research Design, Epidemiology and Biostatistics Core; Rural Health Research and Delivery Core; Translational Research Technologies Core; and the Tracking and Evaluation Core. In summary, by developing the capabilities and resources required for research spanning the broad spectrum of clinical and translational science, the NNE- CTR will provide the platform for enhancing clinical research and health care delivery to support the unique needs of rural northern New England.

Public Health Relevance

The aging and rural populations of northern New England suffer from a number of chronic health issues, including cancer, cardiovascular disease, and substance abuse. The Northern New England Clinical and Translational Research (NNE-CTR) Network, which includes participating and collaborating health care, educational and research institutions in Maine, Vermont, and New Hampshire, will enhance clinical and translational research and its supporting infrastructure in order to support innovative learning, increased effectiveness of clinical research, enhanced rural healthcare delivery systems, and ultimately improved health outcomes in our region.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Justinova, Zuzana
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
United States
Zip Code
Craig, Alexa K; Gerwin, Roslyn; Bainter, Janelle et al. (2018) Exploring Parent Experience of Communication About Therapeutic Hypothermia in the Neonatal Intensive Care Unit. Adv Neonatal Care 18:136-143
Davis-Knowlton, Jessica; Turner, Jacqueline E; Turner, Anna et al. (2018) Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling. Lab Invest :
Juraschek, Stephen P; Plante, Timothy B; Charleston, Jeanne et al. (2018) Use of online recruitment strategies in a randomized trial of cancer survivors. Clin Trials 15:130-138
Tracy, Kirsten M; Tye, Coralee E; Ghule, Prachi N et al. (2018) Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer. Mol Cancer Res 16:587-598
Gilsanz, Vicente; Wren, Tishya A L; Ponrartana, Skorn et al. (2018) Sexual Dimorphism and the Origins of Human Spinal Health. Endocr Rev 39:221-239
Muthukrishnan, Sree Deepthi; Ryzhov, Sergey; Karolak, Michele et al. (2018) Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney. Dis Model Mech 11:
Prudovsky, Igor; Anunciado-Koza, Rea P; Jacobs, Chester G et al. (2018) Mesoderm-specific transcript localization in the ER and ER-lipid droplet interface supports a role in adipocyte hypertrophy. J Cell Biochem 119:2636-2645
Reifsnyder, Peter C; Ryzhov, Sergey; Flurkey, Kevin et al. (2018) Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Leprdb mice. Ann N Y Acad Sci 1418:106-117
Peterson, Sarah M; Turner, Jacqueline E; Harrington, Anne et al. (2018) Notch2 and Proteomic Signatures in Mouse Neointimal Lesion Formation. Arterioscler Thromb Vasc Biol 38:1576-1593
Farrell, Mariah L; Reagan, Michaela R (2018) Soluble and Cell-Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma. Front Endocrinol (Lausanne) 9:218

Showing the most recent 10 out of 21 publications