? PROFESSIONAL DEVELOPMENT CORE The RI-CCTS Professional Development Key Component builds on the state's multiple strengths in education, training, and faculty development. Institutions that are important to this Key Component include Brown's Alpert School of Medicine and its seven affiliated teaching hospitals, Brown's School of Public Health and School of Engineering, and URI's College of Pharmacy and College of Nursing. Faculty at these institutions direct many NIH-funded training and career development programs (e.g., T32s, K12s, R25s), and have extensive mentoring experience. However, significant training and mentoring gaps remain related to Clinical and Translational Research (CTR). With the resources of an IDeA-CTR we will be able to develop a series of critical elements of Professional Development infrastructure that we believe will rapidly transform the RI CTR community. Importantly, our efforts will be focused on the health problems that have been prioritized by the RI Department of Health, including sudden cardiac death, smoking and smoking cessation, obesity, substance abuse and addiction, the elimination new HIV infections, reproductive health, prisoner health, and neuroscience related to mental disorders. We propose the following Specific Aims: 1. Develop new training opportunities that leverage existing institutional resources. Examples of new opportunities are a Mentored Research Award program that will fund three scholars a year, a monthly trans-institutional grant development seminar for all clinical and translational research-oriented career development awardees (e.g., T32s, K12s, R25s) campus-wide, web-based training in interdisciplinary clinical and translational research-oriented topics (e.g., how basic scientists can effectively collaborate with clinicians, and vice versa), and web-based training in how to commercialize research findings. 2. Develop a state-wide mentoring network for clinical and translational research. In addition to developing a comprehensive web-based database of experienced and interested mentors from the Biological Sciences, Public Health, Engineering, Social Sciences, Medicine, Pharmacy, and Nursing, we will develop and implement web-based training for both mentors and mentees in how to optimize the impact of the mentor-mentee relationship. We will give special attention to the mentoring needs of under- represented minorities and women. We believe that the impact of this proposed Professional Development Key Component will be profound because our proposed plan 1) explicitly builds on existing COBRE and INBRE investments, 2) leverages existing institutional resources, and complements these assets with focused new programs and investments, 3) creates infrastructure that links multiple RI institutions in new ways, 4) creates synergies with existing NIH and NSF funded programs, particularly training programs, 5) prioritizes the health needs of the state.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54GM115677-05
Application #
9957175
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Brown University
Department
Type
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Sellke, Nicholas; Kuczmarski, Alex; Lawandy, Isabella et al. (2018) Enhanced coronary arteriolar contraction to vasopressin in patients with diabetes after cardiac surgery. J Thorac Cardiovasc Surg 156:2098-2107
Ollila, Thomas A; Olszewski, Adam J (2018) Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence. Curr Treat Options Oncol 19:38
Potz, Brittany A; Scrimgeour, Laura A; Sabe, Sharif A et al. (2018) Glycogen synthase kinase 3? inhibition reduces mitochondrial oxidative stress in chronic myocardial ischemia. J Thorac Cardiovasc Surg 155:2492-2503
Allawzi, Ayed M; Vang, Alexander; Clements, Richard T et al. (2018) Activation of Anoctamin-1 Limits Pulmonary Endothelial Cell Proliferation via p38-Mitogen-activated Protein Kinase-Dependent Apoptosis. Am J Respir Cell Mol Biol 58:658-667
Chorzalska, Anna; Ahsan, Nagib; Rao, R Shyama Prasad et al. (2018) Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-?B pathways in a model of chronic myeloid leukemia. Mol Oncol 12:630-647
Petrosino, Nicholas J; Zandvakili, Amin; Carpenter, Linda L et al. (2018) Pilot Testing of Peak Alpha Frequency Stability During Repetitive Transcranial Magnetic Stimulation. Front Psychiatry 9:605
Thomas, Kali S; Cote, Danielle; Makineni, Rajesh et al. (2018) Change in VA Community Living Centers 2004-2011: Shifting Long-Term Care to the Community. J Aging Soc Policy 30:93-108
Durand, Wesley M; Stey, Paul C; Chen, Elizabeth S et al. (2018) Trend Analysis of Aggregate Outcomes in Complex Health Survey Data. AMIA Jt Summits Transl Sci Proc 2017:349-358
Pereira, Jorge; Renzulli 2nd, Joseph; Pareek, Gyan et al. (2018) Perioperative Morbidity of Open Versus Minimally Invasive Partial Nephrectomy: A Contemporary Analysis of the National Surgical Quality Improvement Program. J Endourol 32:116-123
Laws, Michael Barton; Michaud, Joanne; Shield, Renee et al. (2018) Comparison of Electronic Health Record-Based and Claims-Based Diabetes Care Quality Measures: Causes of Discrepancies. Health Serv Res 53 Suppl 1:2988-3006

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