The Center for Reproductive Biology Research has been serving the scientific community for approximately 25 years as a P30 Center. Since the center for Population Research of NICHD has changed their application format so that P-30 Center Grants will be eliminated, we have been advised to move to the U54 Center Grant mechanism. The theme chosen and approved for the renewal application is """"""""Mechanisms Involved in Female Reproduction"""""""". The purpose of this Center will be to establish a comprehensive research and training program to investigate the molecular mechanisms governing female reproduction. This research will be accomplished by four research projects. Project I is titled """"""""Steroid receptor activation pathways in female reproductive behavior"""""""", and will investigate the interactions of steroid hormone receptors and neurotransmitters in the regulation of female hypothalamic function. Project II, titled """"""""Transgenic mouse models to study ovarian function,"""""""" will investigate the role of Novel. 1, a member of the TGFb gene family, and Germ Cell Nuclear Factor, a member of the steroid hormone receptor superfamily, in oogenesis and folliculogenesis. Project III, titled """"""""Cellular signals in ovulation and luteinization"""""""", will investigate the regulation and interactions of members of the steroid hormone receptor superfamily in folliculogenesis and luteinization. Finally, Project IV titled """"""""Molecular approaches for the evaluation of human fertility"""""""", will identify the molecular interactions of human zona pellucida proteins with human sperm in the evaluation of human infertility. These research projects will be supported by four Cores. The Cores chosen are the Administrative Core (Core A), the Animal Core (Core B), the Cell Culture Core (Core C) and an Integrated Microscopy Core (Core D). The Administrative Core will provide the Center with centralized management. The Animal Core will serve as a resource for the maintenance and identification of transgenic and knockout mice, as well as, a centralization of the technology required to generate these animals and perform technical surgical manipulations on these animals. The Cell Culture Core will provide investigators with specific reagents for the culture of primary cells and cell lines, as well as, the expertise required to manipulate these cells. The Integrated Microscopy Core will aid investigators in the histological immunohistochemical and ultrastructural analysis required in the execution of their projects. The research in this Center for Reproductive Biology Research application will investigate the molecular regulation of female reproduction and fertility and foster the training of investigators in the field of reproductive biology.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54HD007495-29S2
Application #
6560295
Study Section
Special Emphasis Panel (ZHD1 (08))
Program Officer
Leppert, Phyllis C
Project Start
1978-06-01
Project End
2003-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
29
Fiscal Year
2002
Total Cost
$28,122
Indirect Cost
Name
Baylor College of Medicine
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Piyarathna, Danthasinghe Waduge Badrajee; Rajendiran, Thekkelnaycke M; Putluri, Vasanta et al. (2018) Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder. Eur Urol Focus 4:907-915
Choi, Byung-Kwon; Dayaram, Tajhal; Parikh, Neha et al. (2018) Literature-based automated discovery of tumor suppressor p53 phosphorylation and inhibition by NEK2. Proc Natl Acad Sci U S A 115:10666-10671
Parikh, Neha; Shuck, Ryan L; Gagea, Mihai et al. (2018) Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice. Aging Cell 17:
Kotlajich, Matthew V; Xia, Jun; Zhai, Yin et al. (2018) Fluorescent fusions of the N protein of phage Mu label DNA damage in living cells. DNA Repair (Amst) 72:86-92
Szafran, Adam T; Stossi, Fabio; Mancini, Maureen G et al. (2017) Characterizing properties of non-estrogenic substituted bisphenol analogs using high throughput microscopy and image analysis. PLoS One 12:e0180141
Ha, Kyungsoo; Ma, Chengxian; Lin, Han et al. (2017) The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites. Nat Commun 8:15751
Roarty, K; Pfefferle, A D; Creighton, C J et al. (2017) Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene 36:5958-5968
Aagaard, Kjersti M; Lahon, Anismrita; Suter, Melissa A et al. (2017) Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication. Sci Rep 7:41389
Szafran, Adam T; Stephan, Cliff; Bolt, Michael et al. (2017) High-Content Screening Identifies Src Family Kinases as Potential Regulators of AR-V7 Expression and Androgen-Independent Cell Growth. Prostate 77:82-93
Tsai, Wei-Chih; Reineke, Lucas C; Jain, Antrix et al. (2017) Histone arginine demethylase JMJD6 is linked to stress granule assembly through demethylation of the stress granule-nucleating protein G3BP1. J Biol Chem 292:18886-18896

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