The Primate Core provides a highly specialized, AAALAC approved resource, with the expertise to provide remote infusion and sampling capabilities for researchers using the non-human primate model for reproductive studies. In addition to providing basic housing it has facilities for surgery, laboratory space and secretarial services. It will provide services to three projects of the current proposal (51% total time) and serve four other projects directly relevant to aims of the current proposal. In total, these services are projected to account for 88% of the work load in the first year. The unit is staffed by very experienced personnel and can provide a reliable, virtually unique, resource for the complex animal access methods used extensively in the proposed projects. Dr. Tony Plant has acted as Director for the past two years. It is proposed that he will continue in that capacity. The allocation of Core resources is controlled by the Primate Core Committee, chaired by Dr. Zeleznik. Veterinary care is provided by the Division of Laboratory Animal Resources (DLAR), headed by Dr. Ed Cline. DLAR employs four veterinarians and one of them visits the Primate Facility at least daily. In the present proposal there has been a change in the accounting methods, in the future, research projects will be billed individually for per diem and animal costs, whereas previously, those costs were part of the Core budget.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD008610-28
Application #
6588481
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
28
Fiscal Year
2002
Total Cost
$176,413
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Kawwass, Jennifer F; Sanders, Kristen M; Loucks, Tammy L et al. (2017) Increased cerebrospinal fluid levels of GABA, testosterone and estradiol in women with polycystic ovary syndrome. Hum Reprod 32:1450-1456
Vargas Trujillo, Marcela; Kalil, Bruna; Ramaswamy, Suresh et al. (2017) Estradiol Upregulates Kisspeptin Expression in the Preoptic Area of both the Male and Female Rhesus Monkey (Macaca mulatta): Implications for the Hypothalamic Control of Ovulation in Highly Evolved Primates. Neuroendocrinology 105:77-89
Kalil, Bruna; Ramaswamy, Suresh; Plant, Tony M (2016) The Distribution of Substance P and Kisspeptin in the Mediobasal Hypothalamus of the Male Rhesus Monkey and a Comparison of Intravenous Administration of These Peptides to Release GnRH as Reflected by LH Secretion. Neuroendocrinology 103:711-23
Walker, William H; Easton, Evan; Moreci, Rebecca S et al. (2015) Restoration of spermatogenesis and male fertility using an androgen receptor transgene. PLoS One 10:e0120783
Lomniczi, Alejandro; Wright, Hollis; Castellano, Juan Manuel et al. (2015) Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression. Nat Commun 6:10195
Shahab, M; Trujillo, M Vargas; Plant, T M (2015) A Reevaluation of the Question: Is the Pubertal Resurgence in Pulsatile GnRH Release in the Male Rhesus Monkey (Macaca mulatta) Associated With a Gonad-Independent Augmentation of GH Secretion? Endocrinology 156:3717-24
Verhagen, I; Ramaswamy, S; Teerds, K J et al. (2014) Time course and role of luteinizing hormone and follicle-stimulating hormone in the expansion of the Leydig cell population at the time of puberty in the rhesus monkey (Macaca mulatta). Andrology 2:924-30
Ramaswamy, Suresh; Dwarki, Karthik; Ali, Barkat et al. (2013) The decline in pulsatile GnRH release, as reflected by circulating LH concentrations, during the infant-juvenile transition in the agonadal male rhesus monkey (Macaca mulatta) is associated with a reduction in kisspeptin content of KNDy neurons of the arc Endocrinology 154:1845-53
Terasawa, Ei; Guerriero, Kathryn A; Plant, Tony M (2013) Kisspeptin and puberty in mammals. Adv Exp Med Biol 784:253-73
Stephens, Sahar M; Pau, Francis K Y; Yalcinkaya, Tamer M et al. (2013) Assessing the pulsatility of luteinizing hormone in female vervet monkeys (Chlorocebus aethiops sabaeus). Comp Med 63:432-8

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