Abstract

Research in reproductive biology of the female has overshadowed that in the male. Application of basic and clinical studies to solving problems in human reproduction has been more frequent and more successful in females than in males. Work to be described in this application is designed to increase our basic and clinical knowledge of male reproduction. The primary goals of this work are the study of infertility and contraception in men and the exploration of the basic biology of the male reproductive system important in solving these clinical problems. The studies included range from the molecular biology and biochemistry of the brain, pituitary and testis through the physiology of the endocrine control mechanisms for testicular function in adults to clinical studies on the effects of varicoceles on fertility. The efforts of investigators with varied backgrounds and capabilities are directed toward solving major problems of male reproductive biology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54HD012629-20S1
Application #
2835613
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Leppert, Phyllis C
Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
20
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Chakraborty, Papia; Buaas, F William; Sharma, Manju et al. (2014) LIN28A marks the spermatogonial progenitor population and regulates its cyclic expansion. Stem Cells 32:860-73
Sanz, Elisenda; Evanoff, Ryan; Quintana, Albert et al. (2013) RiboTag analysis of actively translated mRNAs in Sertoli and Leydig cells in vivo. PLoS One 8:e66179
Cazorla, Maxime; Shegda, Mariya; Ramesh, Bhavani et al. (2012) Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels. J Neurosci 32:2398-409
Gill, John C; Navarro, Víctor M; Kwong, Cecilia et al. (2012) Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology 153:4883-93
Anawalt, Bradley D; Hotaling, James M; Walsh, Thomas J et al. (2012) Performance of total testosterone measurement to predict free testosterone for the biochemical evaluation of male hypogonadism. J Urol 187:1369-73
Navarro, Victor M; Ruiz-Pino, Francisco; Sanchez-Garrido, Miguel A et al. (2012) Role of neurokinin B in the control of female puberty and its modulation by metabolic status. J Neurosci 32:2388-97
Navarro, V M; Gottsch, M L; Wu, M et al. (2011) Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. Endocrinology 152:4265-75
Navarro, Victor M; Castellano, Juan M; McConkey, Sarah M et al. (2011) Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab 300:E202-10
Gottsch, Michelle L; Popa, Simina M; Lawhorn, Janessa K et al. (2011) Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology 152:4298-309
Kim, Joshua; Semaan, Sheila J; Clifton, Donald K et al. (2011) Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology 152:2020-30

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