Abstract

Objective The Molecular Histology Core (MHC, formerly Ifnmunotechnology and Histochemistry Core) will continue to provide high-quality, reliable, and cost-effective technical services to participants of the U54 SCCPIR program. The Core will offer routine histological and histochemical techniques, immunocytochemistry, in situ hybridization, and polyclonal antiserum preparation and characterization. The Core will also offer training of research personnel in these techniques. The availability of these techniques will add important new dimensions to studies on molecular mechanisms of reproductive functions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD035041-15
Application #
8248601
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
2014-03-31
Budget Start
2011-04-01
Budget End
2013-03-31
Support Year
15
Fiscal Year
2011
Total Cost
$117,717
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Danshina, Polina V; Qu, Weidong; Temple, Brenda R et al. (2016) Structural analyses to identify selective inhibitors of glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme. Mol Hum Reprod 22:410-26
Franasiak, Jason M; Holoch, Kristin J; Yuan, Lingwen et al. (2014) Prospective assessment of midsecretory endometrial leukemia inhibitor factor expression versus ???3 testing in women with unexplained infertility. Fertil Steril 101:1724-31
Su, Shifeng; Minges, John T; Grossman, Gail et al. (2013) Proto-oncogene activity of melanoma antigen-A11 (MAGE-A11) regulates retinoblastoma-related p107 and E2F1 proteins. J Biol Chem 288:24809-24
Lenhart, Patricia M; Broselid, Stefan; Barrick, Cordelia J et al. (2013) G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection. J Mol Endocrinol 51:191-202
Minges, John T; Su, Shifeng; Grossman, Gail et al. (2013) Melanoma antigen-A11 (MAGE-A11) enhances transcriptional activity by linking androgen receptor dimers. J Biol Chem 288:1939-52
Askew, Emily B; Minges, John T; Hnat, Andrew T et al. (2012) Structural features discriminate androgen receptor N/C terminal and coactivator interactions. Mol Cell Endocrinol 348:403-10
Plante, Beth J; Lessey, Bruce A; Taylor, Robert N et al. (2012) G protein-coupled estrogen receptor (GPER) expression in normal and abnormal endometrium. Reprod Sci 19:684-93
Su, Shifeng; Blackwelder, Amanda J; Grossman, Gail et al. (2012) Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. J Biol Chem 287:34809-24
Goodson, Summer G; Qiu, Yunping; Sutton, Keith A et al. (2012) Metabolic substrates exhibit differential effects on functional parameters of mouse sperm capacitation. Biol Reprod 87:75
Lagarde, William H; Blackwelder, Amanda J; Minges, John T et al. (2012) Androgen receptor exon 1 mutation causes androgen insensitivity by creating phosphorylation site and inhibiting melanoma antigen-A11 activation of NH2- and carboxyl-terminal interaction-dependent transactivation. J Biol Chem 287:10905-15

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