The Training and Education Core will 1) provide direct support and a specialized training program for one pre-doctoral and one postdoctoral trainee;2) provide comprehensive training in muscular dystrophy for all Center participants;and 3) support outreach for education of patients, their families, and physicians in the community. The participating faculty are experienced clinicians and basic scientists intensively involved in education with a history of collaborative interactions. The training pool is composed of a comprehensive set of high-caliber clinical programs and Ph.D. graduate programs at the Ohio State University and Nationwide Children's Hospital. Clinical and basic science trainees will actively participate in a research project aligned with the translational goals of the MDCRC. Basic science trainees will have the opportunity to attend the muscular dystrophy and its ancillary clinics. Coursework that fosters translational research and instruction in the responsible conduct of research will be required for all trainees supported by this core. This cross-discipline training model will be further enriched for all predoctoral and postdoctoral trainees and junior faculty by support of the ongoing Nationwide Children's Hospital and OSU Muscle Study Group. Center participants will also be actively involved in educating patients, their families, local physicians and high school students about research advances in muscular dystrophy. This core will therefore provide comprehensive training required to foster the careers of future generations of clinicians and scientists in the field of muscular dystrophy.
This core will provide training and education for one pre-doctoral and one post-doctoral student each year. The training will be focused around developing comprehensive researchers in muscular dystrophy that combines studies at both the basic and clinical levels.
|Giesige, Carlee R; Wallace, Lindsay M; Heller, Kristin N et al. (2018) AAV-mediated follistatin gene therapy improves functional outcomes in the TIC-DUX4 mouse model of FSHD. JCI Insight 3:|
|Mendell, Jerry R; Sahenk, Zarife; Al-Zaidy, Samiah et al. (2017) Follistatin Gene Therapy for Sporadic Inclusion Body Myositis Improves Functional Outcomes. Mol Ther 25:870-879|
|Eidahl, Jocelyn O; Giesige, Carlee R; Domire, Jacqueline S et al. (2016) Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4. Hum Mol Genet 25:4577-4589|
|Sondergaard, Patricia C; Griffin, Danielle A; Pozsgai, Eric R et al. (2015) AAV.Dysferlin Overlap Vectors Restore Function in Dysferlinopathy Animal Models. Ann Clin Transl Neurol 2:256-70|
|Mendell, Jerry R; Sahenk, Zarife; Malik, Vinod et al. (2015) A phase 1/2a follistatin gene therapy trial for becker muscular dystrophy. Mol Ther 23:192-201|
|Heller, Kristin N; Montgomery, Chrystal L; Shontz, Kimberly M et al. (2015) Human ?7 Integrin Gene (ITGA7) Delivered by Adeno-Associated Virus Extends Survival of Severely Affected Dystrophin/Utrophin-Deficient Mice. Hum Gene Ther 26:647-56|
|Al-Zaidy, Samiah A; Sahenk, Zarife; Rodino-Klapac, Louise R et al. (2015) Follistatin Gene Therapy Improves Ambulation in Becker Muscular Dystrophy. J Neuromuscul Dis 2:185-192|
|Yalvac, Mehmet E; Arnold, William David; Hussain, Syed-Rehan A et al. (2014) VIP-expressing dendritic cells protect against spontaneous autoimmune peripheral polyneuropathy. Mol Ther 22:1353-1363|
|Chicoine, L G; Montgomery, C L; Bremer, W G et al. (2014) Plasmapheresis eliminates the negative impact of AAV antibodies on microdystrophin gene expression following vascular delivery. Mol Ther 22:338-347|
|Chicoine, Louis G; Rodino-Klapac, Louise R; Shao, Guohong et al. (2014) Vascular delivery of rAAVrh74.MCK.GALGT2 to the gastrocnemius muscle of the rhesus macaque stimulates the expression of dystrophin and laminin ?2 surrogates. Mol Ther 22:713-24|
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