The UC Davis MIND Institute IDDRC proposes a Research Project relevant to the Multi-modal Treatment Approaches theme that spans basic and clinical science and utilizes five of the proposed cores. Recent advances in the neurobiology of fragile X syndrome (FXS) have led to targeted treatments that rescue many phenotypic features in the FMRI knock out (KO) mouse and other animal models (Berry-Kravis et al., 2011;Bhakar et al., 2012;Hagerman et al., 2012). Many of these treatments are based on the mGluRS (metabotropic glutamate receptor 5) theory of FXS, which proposes that absence or reduction of FMRP in the full mutation leads to hypersensitivity of the mGluRS pathway to glutamate, which causes intellectual impairments, seizures, and other features of FXS (Bear et al., 2004;Dolen et al., 2007;Huber et al., 2002; Osterweil et al., 2010). In fact, mGluRS antagonists have proven effective in rescuing several FXS-related phenotypes in rodents (Dolen et al., 2010). In contrast to animal studies, therapeutic approaches targeting mGluRS show only modest efficacy in humans (Berry-Kravis et al., 2012). Three factors have contributed to the human findings, (a) Multiple pathways are affected in FXS;thus, targeting only a single pathway is unlikely to fully correct the complex phenotype. Additional targets must be identified so that a polypharmaceutical approach can be developed, (b) The outcome measures used in many clinical trials are not adequate for detecting subtle but meaningful treatment effects. (3) Important treatment-induced changes in brain function may produce only modest short-term changes in observable behavior in individuals with FXS, who have a history of missed and non-normative learning opportunities prior to treatment. It may be possible, however, to """"""""boost"""""""" the phenotypic effects of a drug by adding a behavioral intervention to take advantage of improved brain function.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD079125-02
Application #
8740547
Study Section
Special Emphasis Panel (ZHD1-DSR-H)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
$408,476
Indirect Cost
$143,232
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Kerin, Tara; Volk, Heather; Li, Weiyan et al. (2018) Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder. J Autism Dev Disord 48:137-150
Ozonoff, Sally; Li, Deana; Deprey, Lesley et al. (2018) Reliability of parent recall of symptom onset and timing in autism spectrum disorder. Autism 22:891-896
Benyakorn, Songpoom; Calub, Catrina A; Riley, Steven J et al. (2018) Computerized Cognitive Training in Children With Autism and Intellectual Disabilities: Feasibility and Satisfaction Study. JMIR Ment Health 5:e40
Weir, R K; Bauman, M D; Jacobs, B et al. (2018) Protracted dendritic growth in the typically developing human amygdala and increased spine density in young ASD brains. J Comp Neurol 526:262-274
Edmiston, Elizabeth; Jones, Karen L; Vu, Tam et al. (2018) Identification of the antigenic epitopes of maternal autoantibodies in autism spectrum disorders. Brain Behav Immun 69:399-407
Gangi, Devon N; Schwichtenberg, A J; Iosif, Ana-Maria et al. (2018) Gaze to faces across interactive contexts in infants at heightened risk for autism. Autism 22:763-768
Shen, Mark D; Nordahl, Christine W; Li, Deana D et al. (2018) Extra-axial cerebrospinal fluid in high-risk and normal-risk children with autism aged 2-4 years: a case-control study. Lancet Psychiatry 5:895-904
Pyles, Benjamin; Bailus, Barbara J; O'Geen, Henriette et al. (2018) Purified Protein Delivery to Activate an Epigenetically Silenced Allele in Mouse Brain. Methods Mol Biol 1767:227-239
CastaƱeda, Alejandro R; Pinkerton, Kent E; Bein, Keith J et al. (2018) Ambient particulate matter activates the aryl hydrocarbon receptor in dendritic cells and enhances Th17 polarization. Toxicol Lett 292:85-96
Napoli, Eleonora; Schneider, Andrea; Wang, Jun Yi et al. (2018) Allopregnanolone Treatment Improves Plasma Metabolomic Profile Associated with GABA Metabolism in Fragile X-Associated Tremor/Ataxia Syndrome: a Pilot Study. Mol Neurobiol :

Showing the most recent 10 out of 175 publications