The University of Washington Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center (IDDRC), based at the Center on Human Development and Disability (CHDD), provides a comprehensive interdisciplinary program of research designed to prevent, diagnose, and treat individuals with intellectual and developmental disabilities (IDD). Research is carried out within the framework of the following 8 Collaborative Research Areas (CRAs): (1) Autism and Related Disorders;(2) Brain Malformation Disorders;(3) Central Nervous System Injury;(4) Developmental Toxicology;(5) Environmental Influences and Behavioral Development;(6) Epilepsy;(7) Hearing Disorders, and (8) Learning Disabilities. All CRAs are interdisciplinary, include scientists and clinicians, and are designed to promote translational research. In this application, to facilitate the work of investigators at our IDDRC, we are requesting support for an Administrative Core (Core A) designed to provide scientific and programmatic leadership and four scientific cores: (1) Genetics (Core B) - functional and human genomics components;(2) Brain Imaging (Core C) - in vivo imaging for human studies and animal models;(3) Animal Behavior (Core D) ~ behavioral testing for mouse and non-human primate models;and (4) Clinical Translational (Core E) - promotes and supports all phases of the translational research cycle. The Administrative Core also includes a Behavioral Evaluation Center for behavioral phenotyping for human studies and a test consultation and resource center. We are also proposing to conduct a research project focusing on Joubert syndrome utilizing comprehensive - Omic approaches that is well integrated with cores and other IDDRC activities. Extensive research training and dissemination activities are also integral components of our IDDRC.
We are proposing to support the research projects of over 60 investigators focusing on high priority areas in the field of IDD conducted within an overarching framework of translational research. Combining the expertise of committed and well-established IDD investigators at the University of Washington with core and related University of Washington resources places our IDDRC in a position to make important advances in understanding the underlying causes of and providing effective treatments for individuals with IDD.
|Jing, Jing; Petroff, Rebekah; Shum, Sara et al. (2018) Toxicokinetics and Physiologically Based Pharmacokinetic Modeling of the Shellfish Toxin Domoic Acid in Nonhuman Primates. Drug Metab Dispos 46:155-165|
|Carvill, Gemma L; Liu, Aijie; Mandelstam, Simone et al. (2018) Severe infantile onset developmental and epileptic encephalopathy caused by mutations in autophagy gene WDR45. Epilepsia 59:e5-e13|
|Madhyastha, Tara; Peverill, Matthew; Koh, Natalie et al. (2018) Current methods and limitations for longitudinal fMRI analysis across development. Dev Cogn Neurosci 33:118-128|
|King, Kevin M; McLaughlin, Katie A; Silk, Jennifer et al. (2018) Peer effects on self-regulation in adolescence depend on the nature and quality of the peer interaction. Dev Psychopathol 30:1389-1401|
|Phelps, Ian G; Dempsey, Jennifer C; Grout, Megan E et al. (2018) Interpreting the clinical significance of combined variants in multiple recessive disease genes: systematic investigation of Joubert syndrome yields little support for oligogenicity. Genet Med 20:223-233|
|Chang, Yu-Chi; Cole, Toby B; Costa, Lucio G (2018) Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice. Part Fibre Toxicol 15:18|
|Starr, Michelle C; Askenazi, David J; Goldstein, Stuart L et al. (2018) Impact of processing methods on urinary biomarkers analysis in neonates. Pediatr Nephrol 33:181-186|
|Grant, Kimberly S; Petroff, Rebekah; Isoherranen, Nina et al. (2018) Cannabis use during pregnancy: Pharmacokinetics and effects on child development. Pharmacol Ther 182:133-151|
|Parada, Carolina Angelica; Osbun, Joshua; Kaur, Sumanpreet et al. (2018) Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression. Sci Rep 8:2098|
|Jansen, Sandra; Hoischen, Alexander; Coe, Bradley P et al. (2018) A genotype-first approach identifies an intellectual disability-overweight syndrome caused by PHIP haploinsufficiency. Eur J Hum Genet 26:54-63|
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