The Center for Big Data in Translational Genomics administrative support will facilitate the effective collaboration of team members across three countries in reaching Center research aims. This support will provide technical and administrative infrastructure to assess the effectiveness of the Center, technical infrastructure for compute platforms and software development spanning industry and academia, and it will support consortium-wide activities such as general collaboration, metadata analysis and sharing, and open competitions.

Public Health Relevance

By setting up infrastructure to operate openly and internationally, and with the participation of key players in industry, the Center will enable the global data and methods sharing necessary to bring genomics into the big data era, and thus obtain the statistical power we need to use genomics to understand disease and develop new precision treatments.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HG007990-04
Application #
9277522
Study Section
Special Emphasis Panel (ZRG1-BST-R)
Project Start
Project End
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
4
Fiscal Year
2017
Total Cost
$454,504
Indirect Cost
$171,235
Name
University of California Santa Cruz
Department
Type
Domestic Higher Education
DUNS #
125084723
City
Santa Cruz
State
CA
Country
United States
Zip Code
95064
Kronenberg, Zev N; Fiddes, Ian T; Gordon, David et al. (2018) High-resolution comparative analysis of great ape genomes. Science 360:
Jain, Miten; Olsen, Hugh E; Turner, Daniel J et al. (2018) Linear assembly of a human centromere on the Y chromosome. Nat Biotechnol 36:321-323
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Ellrott, Kyle; Bailey, Matthew H; Saksena, Gordon et al. (2018) Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines. Cell Syst 6:271-281.e7
Fiddes, Ian T; Armstrong, Joel; Diekhans, Mark et al. (2018) Comparative Annotation Toolkit (CAT)-simultaneous clade and personal genome annotation. Genome Res 28:1029-1038
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Tyson, John R; O'Neil, Nigel J; Jain, Miten et al. (2018) MinION-based long-read sequencing and assembly extends the Caenorhabditis elegans reference genome. Genome Res 28:266-274
Jain, Miten; Koren, Sergey; Miga, Karen H et al. (2018) Nanopore sequencing and assembly of a human genome with ultra-long reads. Nat Biotechnol 36:338-345
Computational Pan-Genomics Consortium (2018) Computational pan-genomics: status, promises and challenges. Brief Bioinform 19:118-135
Kolmogorov, Mikhail; Armstrong, Joel; Raney, Brian J et al. (2018) Chromosome assembly of large and complex genomes using multiple references. Genome Res 28:1720-1732

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