The Principal Investigator (PI), Dr. Stuart, assisted by the Senior Investigator, Dr. Dampier, will be responsiblefor the overall conduct of grant associated functions and for clinical care provided at the Center's 3 sites as thisrelates to the conduct of the Intra and Inter-Network Clinical Trials. Administrative Core responsibility willinclude the monitoring of the scientific progress of all projects and associated costs, optimal and efficientdissemination and data sharing between project investigators, and NIH Statistical Center and the nurturing ofnew scientific ideas. The PI will provide leadership in all aspects of the Center's activities, and will arbitrateany differences that potentially arise between personnel. The PI and Dr. Dampier will provide the leadership incollaborative investigations between the Marian Anderson Sickle Cell Anemia Care and Research Center andinvestigators at the other NIH Comprehensive Sickle Cell Centers. They will work with the NIH Heart, Bloodand Lung Institute program director and grants management personnel, and the medical and administrativeleadership at 3 involved Universities - Jefferson, Drexel and the University of Louisville at Kentucky. Besidesbiweekly meetings of staff as described, an Internal Advisory Committee comprising Principal and Co-PrincipalInvestigators on the various subprojects and clinical cores will meet every three months to monitor scientificprogress, optimize fiscal planning and discuss new directions and day-to-day problems. An External AdvisoryCommittee will meet with the Research Group on an annual basis, provide insight and critical reviews of theCenter's progress and aid in future direction. The PI will maintain an annual report of all Center's activities -scientific research and clinical trials, fiscal matters, patient care activities, educational and counseling, andcommunity outreach. The NIH Statistical Center will provide ongoing statistical expertise and support and wewill cooperate fully with this Center. The core will provide day-to-day support functions for all investigatorsincluding financial grant management in conjunction with the grant management operations at the respectiveMedical Schools. Other support functions will include secretarial assistance, the facilitation of requests forsupplies, equipment maintenance contracts, the hiring of support personnel, the scheduling of all Centermeetings, the maintenance of records, meeting minutes, travel arrangements, and the other mundane butimportant daily chores that will keep the operation running smoothly. As outlined in detail, the PI and principalco-investigator will continue their extensive involvement in Inter-Center related administrative activities.
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