The Southwestern Comprehensive Sickle Cell Center will include as a key component a Sickle Cell Scholar Program. The purpose of this program will be to offer comprehensive multi-disciplinary training to postdoctoral professionals who desire to excel at a career in investigation, teaching, and patient care involving sickle cell disease. The milieu at UT Southwestern and its affiliated institutions for providing such training is outstanding. For over a decade the Pediatric Hematology-Oncology Program at UT Southwestern has been the recipient of a T32 Institutional NRSA Training Grant from the National Cancer Institute and has successfully trained 16 young physicians as pediatric hematology oncology specialists. The well-developed and effective infrastructure that has been established for this fellowship program - which has been directed by Dr. George R. Buchanan (the proposed Center Director and Scholar Program Mentor) - will be employed for the Sickle Cell Scholar Program as well. In addition, resources in the Department of Pediatrics and UT Southwestern as a whole will be used as a part of the scholars' training, including involvement in the NIH K30 Curriculum Award Program and School of Public Health. Individuals from all disciplines, whether or not they have previously received training at UT Southwestern or another participating Center institution in Texas and Oklahoma, are eligible, and an active recruitment effort is planned with particular emphasis on recruiting and training minority scientists. A Scholar Selection Committee and Scholar Advisory Committee will identify and nominate candidates and then guide them and monitor their progress. The proposed Southwestern Comprehensive Sickle Cell Center is well positioned to train tomorrow's leaders in sickle cell research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL070588-05
Application #
7409093
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
5
Fiscal Year
2007
Total Cost
$161,104
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Becker, Amy M; Goldberg, Jordan H; Henson, Michael et al. (2014) Blood pressure abnormalities in children with sickle cell anemia. Pediatr Blood Cancer 61:518-22
Vetter, Courtney L; Buchanan, George R; Quinn, Charles T (2014) Burden of diagnostic radiation exposure in children with sickle cell disease. Pediatr Blood Cancer 61:1322-4
McCavit, Timothy L; Xuan, Lei; Zhang, Song et al. (2013) National trends in incidence rates of hospitalization for stroke in children with sickle cell disease. Pediatr Blood Cancer 60:823-7
McCavit, Timothy L; Lin, Hua; Zhang, Song et al. (2011) Hospital volume, hospital teaching status, patient socioeconomic status, and outcomes in patients hospitalized with sickle cell disease. Am J Hematol 86:377-80
Dale, Juanita Conkin; Cochran, Cindy J; Roy, Lonnie et al. (2011) Health-related quality of life in children and adolescents with sickle cell disease. J Pediatr Health Care 25:208-15
McCavit, Timothy L; Quinn, Charles T; Techasaensiri, Chonnamet et al. (2011) Increase in invasive Streptococcus pneumoniae infections in children with sickle cell disease since pneumococcal conjugate vaccine licensure. J Pediatr 158:505-7
Quinn, Charles T; Stuart, Marie J; Kesler, Karen et al. (2011) Tapered oral dexamethasone for the acute chest syndrome of sickle cell disease. Br J Haematol 155:263-7
Becker, Amy M (2011) Sickle cell nephropathy: challenging the conventional wisdom. Pediatr Nephrol 26:2099-109
Neelam, Sudha; Kakhniashvili, David G; Wilkens, Stephan et al. (2011) Functional 20S proteasomes in mature human red blood cells. Exp Biol Med (Maywood) 236:580-91
Ghatpande, Swati S; Choudhary, Pankaj K; Quinn, Charles T et al. (2010) In vivo pharmaco-proteomic analysis of hydroxyurea induced changes in the sickle red blood cell membrane proteome. J Proteomics 73:619-26

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