Goals of the Sickle Cell Scholar program are to provide protected time and resources necessary for a young investigator to pursue original research relevant to understanding the genetics, pathophysiology, psychology or treatment of sickle cell disease. The Sickle Cell Center will facilitate productive interactions between the Scholar, other members of the Sickle Cell Center, the medical community of Boston and sickle cell disease investigators throughout the nation and provide an infrastructure to allow the Sickle Cell Scholar ultimately to pursue a career of peer-reviewed independent research. A career plan will be individualized based upon the interests and ambitions of the candidate. The opportunity for the scholar to engage in either basic or clinical , research will be available. However, a particular focus of the center is to foster career development of physician-scientists committed to clinical translational research. Available at our institutions are many courses and seminar series on conducting clinical or basic investigations,including bioethics, biostatistics and epidemiology. Training programs, including the NIH-funded K30 award are available to individuals with an !interest in clinical or translational research. This program focuses on approaches to clinical investigation and provides basic quantitative and study design skills essential for clinical investigations. One year before the term of our current Sickle Cell Scholar ends, investigators of the sickle cell center will be notified of the recompetition of the Scholar position and asked to search for promising candidates who meet the criteria for the Sickle Cell Scholar. A special committee will review the applications and recommend a candidate to the Center Director, based on: quality of science proposed; likelihood of a continuing career in biomedical science relevant to sickle cell disease; relationship to ongoing research in the center, mentor's credentials and training record; suitability of the mentor-trainee relationship; training and record of the candidate; institutional support for the position.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL070819-04
Application #
7213264
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
4
Fiscal Year
2006
Total Cost
$90,000
Indirect Cost
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Maron, Bradley A; Oldham, William M; Chan, Stephen Y et al. (2014) Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation 130:168-79
Cottrill, Katherine A; Chan, Stephen Y; Loscalzo, Joseph (2014) Hypoxamirs and mitochondrial metabolism. Antioxid Redox Signal 21:1189-201
Loscalzo, Joseph; Handy, Diane E (2014) Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series). Pulm Circ 4:169-74
Zhao, Yuzheng; Yang, Yi; Loscalzo, Joseph (2014) Real-time assessment of the metabolic profile of living cells with genetically encoded NADH sensors. Methods Enzymol 542:349-67
Barroso, Madalena; Florindo, Cristina; Kalwa, Hermann et al. (2014) Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem 289:15350-62
Joseph, Jacob; Loscalzo, Joseph (2013) Selenistasis: epistatic effects of selenium on cardiovascular phenotype. Nutrients 5:340-58
Maron, Bradley A; Tang, Shiow-Shih; Loscalzo, Joseph (2013) S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. Antioxid Redox Signal 18:270-87
Maron, Bradley A; Waxman, Aaron B; Opotowsky, Alexander R et al. (2013) Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials). Am J Cardiol 112:720-5
Handy, Diane E; Loscalzo, Joseph; Leopold, Jane A (2013) Systems analysis of oxidant stress in the vasculature. IUBMB Life 65:911-20
Nallamshetty, Shriram; Chan, Stephen Y; Loscalzo, Joseph (2013) Hypoxia: a master regulator of microRNA biogenesis and activity. Free Radic Biol Med 64:20-30

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