Abstract

The Cardiac Imaging Core is an interdisciplinary resource that will provide comprehensive expertise in cardiac magnetic resonance and computed tomography imaging and analysis to optimally characterize the efficacy of cell therapy following myocardial infarction in all SCCT projects. This imaging core will function as part of a recently established network of resources and activities dedicated to phenotyping human cardiovascular disease and experimental pathology in several large ongoing multidisciplinary efforts at the Johns Hopkins School of Medicine. The mission of this facility is to offer state of the art imaging acquisition and analysis techniques that not only fulfill the aims and research objectives of the individual projects described in this application, but also facilitate the expansion of new hypothesisdriven biomedical imaging research. Intense multidisciplinary intellectual collaboration will ensure a strong synergism that will undoubtedly benefit the execution of tasks involving imaging and analysis in this SCCT application.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
7U54HL081028-03
Application #
7500740
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
3
Fiscal Year
2007
Total Cost
$109,670
Indirect Cost

  Institution

Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048

  Publications

Ramireddy, Archana; Brodt, Chad R; Mendizabal, Adam M et al. (2017) Effects of Transendocardial Stem Cell Injection on Ventricular Proarrhythmia in Patients with Ischemic Cardiomyopathy: Results from the POSEIDON and TAC-HFT Trials. Stem Cells Transl Med 6:1366-1372
Golpanian, Samuel; El-Khorazaty, Jill; Mendizabal, Adam et al. (2015) Effect of aging on human mesenchymal stem cell therapy in ischemic cardiomyopathy patients. J Am Coll Cardiol 65:125-32
Yoneyama, Kihei; Lima, João A C (2015) Alcohol consumption and myocardial remodeling in elderly women and men. Circ Cardiovasc Imaging 8:
Magalhães, Tiago A; Kishi, Satoru; George, Richard T et al. (2015) Combined coronary angiography and myocardial perfusion by computed tomography in the identification of flow-limiting stenosis - The CORE320 study: An integrated analysis of CT coronary angiography and myocardial perfusion. J Cardiovasc Comput Tomogr 9:438-45
Heldman, Alan W; DiFede, Darcy L; Fishman, Joel E et al. (2014) Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial. JAMA 311:62-73
Suncion, Viky Y; Ghersin, Eduard; Fishman, Joel E et al. (2014) Does transendocardial injection of mesenchymal stem cells improve myocardial function locally or globally?: An analysis from the Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis (POSEIDON) randomized trial. Circ Res 114:1292-301
Karantalis, Vasileios; DiFede, Darcy L; Gerstenblith, Gary et al. (2014) Autologous mesenchymal stem cells produce concordant improvements in regional function, tissue perfusion, and fibrotic burden when administered to patients undergoing coronary artery bypass grafting: The Prospective Randomized Study of Mesenchymal Stem Ce Circ Res 114:1302-10
Donekal, Sirisha; Venkatesh, Bharath A; Liu, Yuan Chang et al. (2014) Interstitial fibrosis, left ventricular remodeling, and myocardial mechanical behavior in a population-based multiethnic cohort: the Multi-Ethnic Study of Atherosclerosis (MESA) study. Circ Cardiovasc Imaging 7:292-302
Malliaras, Konstantinos; Makkar, Raj R; Smith, Rachel R et al. (2014) Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction). J Am Coll Cardiol 63:110-22
Williams, Adam R; Hatzistergos, Konstantinos E; Addicott, Benjamin et al. (2013) Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. Circulation 127:213-23

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