The administrative structure of the Sickle Cell Scholar is specifically designed so that Dr. Hillery andDr. DeBaun can work together to identify trainees and foster their career growth and development of sicklecell disease-related translational research. Recruitment for the scholar will target young investigatorscurrently involved in sickle cell disease or pediatric asthma research, including Postdoctoral Fellows andJunior Faculty. The Scholar can be based at either the Medical College of Wisconsin or WashingtonUniversity School of Medicine. The selected candidate will participate in the proposed TranslationalProjects, which is based at both sites, to ensure his or her scholarly and practical exposures willsufficiently encompass training in either basic science or clinical research. The Scholar will be expected todevelop a novel aspect of the theme developed in Translational Project 5 so as to complete noteworthyresearch that significantly augments our understanding of the interaction of the inflammatory pathways andpulmonary disease with sickle cell disease. The Sickle Cell Scholar will be expected to spend at least 75percent of his/her effort towards this project, including career development activities. In addition, theSickle Cell Scholar will be encouraged and mentored to apply for funding to support new interests that mayresult from their participation in Project 5. A Scholar Advisory Committee that will include both MedicalCollege of Wisconsin and Washington University School of Medicine-based faculty, and external membersas needed, will function to provide the Scholar with continuing advice on his/her research program. As coleadersof Project 5, Drs. Hillery and DeBaun will devote a minimum of 5% joint effort, which will beincluded within the overall Project 5 effort. Cheryl Hillery and Michael DeBaun, Co-Mentors, will beresponsible for tracking and evaluation of the Sickle Cell Scholar. The proposed Sickle Cell Scholarprogram aims to increase the critical mass of qualified investigators who possess the expertise and careermotivation to conduct research in Sickle Cell Disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54HL090503-01
Application #
7458420
Study Section
Special Emphasis Panel (ZHL1-CSR-O (F1))
Project Start
2008-06-15
Project End
2012-03-31
Budget Start
2008-06-15
Budget End
2009-03-31
Support Year
1
Fiscal Year
2008
Total Cost
$159,075
Indirect Cost
Name
Medical College of Wisconsin
Department
Type
DUNS #
937639060
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
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Wandersee, Nancy J; Maciaszek, Jamie L; Giger, Katie M et al. (2015) Dietary supplementation with docosahexanoic acid (DHA) increases red blood cell membrane flexibility in mice with sickle cell disease. Blood Cells Mol Dis 54:183-8
Xu, Hao; Wandersee, Nancy J; Guo, YiHe et al. (2014) Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation. Blood 124:3978-81
Brandow, Amanda M; Farley, Rebecca A; Panepinto, Julie A (2014) Neuropathic pain in patients with sickle cell disease. Pediatr Blood Cancer 61:512-7
Panepinto, Julie A; Torres, Sylvia; Bendo, Cristiane B et al. (2014) PedsQLâ„¢ Multidimensional Fatigue Scale in sickle cell disease: feasibility, reliability, and validity. Pediatr Blood Cancer 61:171-7

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