The objective of the Administrative Core will be to provide management, coordination, and support of CSCCactivities, including oversight and travel costs for internal and external advisory committees, travel costs forCSCC staff, and support for key personnel such as the Center Director and an administrative assistant. TheCenter Director, Dr. Victor Gordeuk, will have overall responsibility for the scientific and fiscal implementationof the proposed program. He will chair the Internal Advisory Committee of the Center. Each of the Center'sIndividual project investigators will answer fiscally and administratively to the Center director. In accordanceto Howard University policy and as an official at a department head level, the director will review, authorizeand sign all requests for services and purchases, as well as requests for budgetary transfers relating toCenter grant funds.The Internal Advisory Committee will facilitate internal governance and operations, and oversee collaborativearrangements among Center investigators. It shall consist of the Washington Area CSCC Center Directorplus the Principal Investigators of the inter-Center clinical study, the intra-Center clinical study, the patientoutcomes and the transnational research studies, as well as the Clinical - and the Patient Outcomes Cores.There will be two external advisory bodies: the External Advisory Committee and a Community AdvisoryCouncil. The External Advisory Committee will be composed of three completely independent SCDinvestigators selected because of their nationally recognized expertise and will review the Center program atleast once a year. The Community Advisory Council, will have Washington area residents knowledgeable ofthe needs of patients with SCD. The goals of the Advisory Council will be to provide advice and counsel tothe Center's director and administrative staff for (a) maintaining good communications with the communitiesserved by our collaborating institutions, (b) stimulating research activities into problems that are a perceivedneed of the patients and communities, (c) improving patient care and consideration of the perspectives ofpatients and families, and (d) coordinating community education and counseling programs.Additional components in this Core are support for a Center web site and for a sickle cell summer scienceprogram for high school students.