There is an urgent need to increase the critical mass of dedicated junior MD and Ph.D. investigators properly trained in research methods who are able or willing to apply their knowledge to the study of sickle cell disease1. There are significant barriers to the success of physicians choosing to pursue integrated basic and clinical research careers2""""""""4. These include an increased time commitment required for research training, increased educational indebtedness of medical school and competing patient care demands. For Ph.D. students, training outside of traditional scientific course work is required to ensure that they can communicate effectively with their physician colleagues, and utilize research results to decrease disease burden. The Scholar Program will utilize an academic advisor, scientific mentors and the established programs of training at WACSCC and local institutions to ensure that a well integrated training program is developed and implemented during this award.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54HL090508-02S2
Application #
7988366
Study Section
Special Emphasis Panel (ZHL1-CSR-O (F1))
Project Start
2009-07-10
Project End
2010-06-30
Budget Start
2009-07-10
Budget End
2010-06-30
Support Year
2
Fiscal Year
2009
Total Cost
$12,650
Indirect Cost
Name
Howard University
Department
Type
DUNS #
056282296
City
Washington
State
DC
Country
United States
Zip Code
20059
Tatari-Calderone, Zohreh; Gordish-Dressman, Heather; Fasano, Ross et al. (2016) Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease. Hum Immunol 77:35-40
Glass, Penny; Brennan, Tara; Wang, Jichuan et al. (2013) Neurodevelopmental deficits among infants and toddlers with sickle cell disease. J Dev Behav Pediatr 34:399-405
Luban, Naomi L C; McBride, Eileen; Ford, Jason C et al. (2012) Transfusion medicine problems and solutions for the pediatric hematologist/oncologist. Pediatr Blood Cancer 58:1106-11
Sachdev, Vandana; Kato, Gregory J; Gibbs, J Simon R et al. (2011) Echocardiographic markers of elevated pulmonary pressure and left ventricular diastolic dysfunction are associated with exercise intolerance in adults and adolescents with homozygous sickle cell anemia in the United States and United Kingdom. Circulation 124:1452-60
Kasvosve, Ishmael; Debebe, Zufan; Nekhai, Sergei et al. (2010) Ferroportin (SLC40A1) Q248H mutation is associated with lower circulating plasma tumor necrosis factor-alpha and macrophage migration inhibitory factor concentrations in African children. Clin Chim Acta 411:1248-52
Nouraie, Mehdi; Reading, Noel S; Campbell, Andrew et al. (2010) Association of G6PD with lower haemoglobin concentration but not increased haemolysis in patients with sickle cell anaemia. Br J Haematol 150:218-25
Aliyu, Zakari Y; Suleiman, Aisha; Attah, Ester et al. (2010) NT-proBNP as a marker of cardiopulmonary status in sickle cell anaemia in Africa. Br J Haematol 150:102-7