The Sickle Cell Scholar training program is an integral part of the education component of the Comprehensive Sickle Cell Center grant. The Sickle Cell Scholar will be chosen according to the guidelines in the RFA. Under the auspices of the Los Angeles Sickle Cell Center, the scholar will have the opportunity to do clinical and translational research related to the efficacy of L-glutamine in ameliorating the symptoms of sickle cell disease, the genesis of cardiac dysfunction in transfused sickle cell patients, the health services research related to provision of adult care, or translational research related to the role of viscosity in alteration of blood flow and oxygen delivery in humans and the use of engineering techniques to detect evidence of sickling. Unique to this program, the scholar will be supervised by the Center education director who is a cell biologist and doctoral level educator. This individual will be responsible for setting educational milestones and systematically monitoring the progress of the scholar to the training program. Also described here is a plan for the management of the summer high school student program that will also be run by the Center education director.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL090511-02
Application #
7879418
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
2
Fiscal Year
2009
Total Cost
$165,375
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
052277936
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
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Rabai, Miklos; Detterich, Jon A; Wenby, Rosalinda B et al. (2014) Deformability analysis of sickle blood using ektacytometry. Biorheology 51:159-70
Sonmez, Melda; Ince, Huseyin Yavuz; Yalcin, Ozlem et al. (2013) The effect of alcohols on red blood cell mechanical properties and membrane fluidity depends on their molecular size. PLoS One 8:e76579
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Detterich, Jon A; Sangkatumvong, Suvimol; Kato, Roberta et al. (2013) Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion. Transfusion 53:1059-68
Detterich, Jon; Alexy, Tamas; Rabai, Miklos et al. (2013) Low-shear red blood cell oxygen transport effectiveness is adversely affected by transfusion and further worsened by deoxygenation in sickle cell disease patients on chronic transfusion therapy. Transfusion 53:297-305
Alexy, Tamas; Baskurt, Oguz K; Nemeth, Norbert et al. (2011) Effect of lanthanides on red blood cell deformability and response to mechanical stress: role of lanthanide ionic radius. Biorheology 48:173-83

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