Abstract

There will be three Human Biology Cores. Core I (K) will explore source of variability in NSAID action. Core II (L) will study mechanisms of NSAID actions in pain and inflammation and in the cardiovascular system. Core III will be activated in the second funding cycle (year 5-10) and will address prospectively hypotheses that have emerged from the overall program in the first funding cycle.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HL117798-02
Application #
8516103
Study Section
Special Emphasis Panel (ZGM1-PPBC-0)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2013
Total Cost
$440,860
Indirect Cost
$59,753

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Chen, Lihong; Yang, Guangrui; Zhang, Jiayang et al. (2018) Time-Dependent Hypotensive Effect of Aspirin in Mice. Arterioscler Thromb Vasc Biol 38:2819-2826
Song, Wen-Liang; Ricciotti, Emanuela; Liang, Xue et al. (2018) Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice. J Pharmacol Exp Ther 367:425-432
Wang, Dandan; Hu, Xiaoyue; Lee, Seung Hee et al. (2018) Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation. JACC Basic Transl Sci 3:350-362
Di Giovanni, James P; Barkley, Robert M; Jones, David N M et al. (2018) Tandem Mass Spectrometry and Ion Mobility Reveals Structural Insight into Eicosanoid Product Ion Formation. J Am Soc Mass Spectrom 29:1231-1241
Paschos, Georgios K; Tang, Soon Yew; Theken, Katherine N et al. (2018) Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2. Cell Rep 24:809-814
Zhou, Jian; Theesfeld, Chandra L; Yao, Kevin et al. (2018) Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk. Nat Genet 50:1171-1179
Okuno, Toshiaki; Gijón, Miguel A; Zarini, Simona et al. (2018) Altered eicosanoid production and phospholipid remodeling during cell culture. J Lipid Res 59:542-549
Ricciotti, Emanuela; Castro, Cecilia; Tang, Soon Yew et al. (2018) Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs. Circulation 138:2367-2378
Theken, Katherine N; Grosser, Tilo (2018) Weight-adjusted aspirin for cardiovascular prevention. Lancet 392:361-362
Lin, Nan; Shay, Jessica E S; Xie, Hong et al. (2018) Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis. Front Immunol 9:2565

Showing the most recent 10 out of 91 publications